Eumycetoma and actinomycetoma--an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy

Journal of the European Academy of Dermatology and Venereology : JEADV
P NenoffH Schöfer

Abstract

Mycetoma is a chronic putrid infection of the cutaneous and subcutaneous tissue concerning predominantly the feet, and more rarely other body parts. Mycetoma can be caused by both fungi (eumycetoma) and bacteria (actinomycetoma). Mode of infection is an inoculation of the causative microorganism via small injuries of the skin. The clinical correlate of both forms of mycetoma is tumescence with abscesses, painless nodules, sinuses and discharge. The latter is commonly serous-purulent and contains grains (filamentous granules) which can be expressed for diagnostic purposes. Distinctive for both eumycetoma and actinomycetoma, are the formation of grains. Grains represent microcolonies of the microorganism in vivo in the vital tissue. The most successful treatment option for eumycetomas offers itraconazole in a dosage of 200 mg twice daily. This triazole antifungal is considered as 'gold standard' for eumycetomas. Alternatively, the cheaper ketoconazole was widely used, however, it was currently stopped by the FDA. Actinomycetomas should be treated by the combination of trimethoprim-sulphamethoxazole (co-trimoxazole 80/400 to 160/800 mg per day) and amikacin 15 mg/kg body weight per day. Mycetomas are neglected infections of the po...Continue Reading

References

Oct 1, 1977·Thoraxchirurgie, Vaskuläre Chirurgie·D MackA Harlacher
Jan 1, 1982·Journal of the American Academy of Dermatology·R F Palestine, R S Rogers
Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·R J Hay, D W Mackenzie
Mar 1, 1980·American Journal of Clinical Pathology·B C West, K J Kwon-Chung
May 1, 1995·Journal of the American Academy of Dermatology·M W LeeD L Greer
Jan 1, 1994·Journal of Clinical Pathology·S H Mirza, C Campbell
Mar 21, 1998·Journal of Clinical Microbiology·A O Ahmed, E S Abugroun
May 13, 1999·International Journal of Dermatology·P MahaisavariyaS Khemngern
Jul 25, 2000·The British Journal of Dermatology·N Soto-Mendoza, A Bonifaz
Nov 4, 2000·Journal of Clinical Microbiology·B M HemashettarF W Chandler
Feb 24, 2001·Acta Dermato-venereologica·M RamamU Banerjee
Jul 31, 2001·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·B ManzU F Haustein
Mar 7, 2002·Journal of Clinical Microbiology·Abdalla AhmedSybren de Hoog
Jan 22, 2003·The British Journal of Dermatology·S AamirT Haroon
Feb 1, 2006·International Journal of Dermatology·Bassirou N'diayeRajesh Bakshi
Apr 1, 1994·Journal of Near Eastern Studies·J V Kinnier Wilson
Mar 24, 2006·Revista Do Instituto De Medicina Tropical De São Paulo·Ricardo NegroniAngela Restrepo
Aug 23, 2006·Mycoses·Kamer GündüzGülgün Yilmaz Ovali
Jun 15, 2007·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M MeissnerR Kaufmann
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wendy W J van de SandeAlex van Belkum
Jul 1, 1949·Radiology·D S CARROLL
Aug 8, 2009·International Journal of Dermatology·Hendrick M MotswalediDick L Nemutavhanani
Sep 24, 2009·Current Opinion in Infectious Diseases·Marcia GarnicaFlavio Queiroz-Telles
Jan 26, 2010·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Pietro NenoffGail Davey
Jan 30, 2010·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·N El MuttardiB Jemec
Jan 6, 2011·FEMS Immunology and Medical Microbiology·Blanca Edith Millán-ChiuRubén López-Martínez
Jan 18, 2011·Medical Mycology·H MachmachiJ B Poirat
Jan 21, 2011·Transactions of the Royal Society of Tropical Medicine and Hygiene·A H FahalE E Zijlstra
Mar 30, 2011·The International Journal of Lower Extremity Wounds·M MaloneF Bowling
Jul 26, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·X IriartP Couppié
Nov 4, 2011·The American Journal of Tropical Medicine and Hygiene·Fernanda CordeiroCarmelia Reis
Dec 30, 2011·Journal of Clinical Microbiology·G Sybren de HoogWendy W J van de Sande
Jan 10, 2012·The Indian Journal of Radiology & Imaging·Anitha Sen, Rajesh Subramonia Pillay
Feb 16, 2012·The International Journal of Lower Extremity Wounds·Sandhya VenkatswamiShobana Subramanyam
Jun 6, 2012·The American Journal of Tropical Medicine and Hygiene·Oriol MitjàQuique Bassat
Jun 12, 2012·Clinics in Dermatology·Oliverio WelshMario Cesar Salinas
Jun 12, 2012·Clinics in Dermatology·Roberto EstradaOliverio Welsh
Jul 5, 2012·Journal of Clinical Microbiology·Najwa A MhmoudWendy W J van de Sande
Jul 20, 2012·Mediterranean Journal of Hematology and Infectious Diseases·Sanjeev Kumar SharmaHaraprasad Pati
Jul 25, 2012·Antonie van Leeuwenhoek·Mario Cesar Salinas-CarmonaOliverio Welsh
Aug 3, 2012·Transactions of the Royal Society of Tropical Medicine and Hygiene·Hagir A M ZeinManar E Abdel-Rahman
Sep 12, 2012·Antimicrobial Agents and Chemotherapy·Wendy KloezenWendy W J van de Sande

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Citations

Jun 5, 2016·Journal de mycologie médicale·M Develoux
Jul 5, 2016·Actas dermo-sifiliográficas·J E Carrasco-ZuberD Berroeta-Mauriziano
Jun 24, 2016·PLoS Neglected Tropical Diseases·Suleiman Hussein SuleimanAhmed Hassan Fahal
Jan 31, 2017·The American Journal of Dermatopathology·Eduardo Castro-EcheverryMartin P Fernandez
Nov 19, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·N CunhaJ Cabete
Jul 11, 2019·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·B MalisiewiczH Schöfer
Feb 26, 2020·PLoS Neglected Tropical Diseases·Jesús Alberto Cárdenas-de la GarzaLucio Vera-Cabrera
May 1, 2020·PLoS Neglected Tropical Diseases·Rayan S AliAhmed Hassan Fahal
Jul 19, 2017·The American Journal of Tropical Medicine and Hygiene·Ohad BitanEli Schwartz
Dec 12, 2018·PLoS Neglected Tropical Diseases·Mustafa AbbasAhmed Hassan Fahal
Mar 20, 2019·Mycopathologia·Ruojun WangRuoyu Li
Apr 18, 2020·Microbiology Resource Announcements·El Shiekh KhidirAl Amin Ibrahim
May 22, 2020·Current Dermatology Reports·Samuel YeroushalmiAdam Friedman
Aug 10, 2017·Revista Do Instituto De Medicina Tropical De São Paulo·Alexandro BonifazAndrés Tirado-Sánchez
Apr 12, 2018·Anais Brasileiros De Dermatologia·Carmelia Matos Santiago Reis, Eugenio Galdino de Mendonça Reis-Filho
May 11, 2018·PLoS Neglected Tropical Diseases·Sahar Mubarak BakhietHajo Mohamed El Amin
May 3, 2018·Dermatopathology·Gianluca Nazzaro, Stefano Veraldi
Nov 2, 2018·Journal of Fungi·Daniel Elad
Apr 28, 2017·The Journal of Dermatology·Hiroko D NambaKenji Asagoe
Apr 17, 2019·Transactions of the Royal Society of Tropical Medicine and Hygiene·Alfonso Santiago-TéllezJorge Ismael Castañeda-Sánchez
Aug 28, 2020·PLoS Neglected Tropical Diseases·Lamis Y M ElkheirAhmed Hassan Fahal
Sep 25, 2020·PLoS Neglected Tropical Diseases·Darcy Emery, David W Denning
Jan 25, 2019·Tropical Medicine and Health·Mohamed D A GismallaLamia S Hamed
Mar 25, 2020·The American Journal of Dermatopathology·Preetha KamathPaolo Romanelli
Jul 24, 2020·Pakistan Journal of Biological Sciences : PJBS·Moawia GameraddinHassan Ali Hamad
Oct 20, 2020·Frontiers in Immunology·Derry K Mercer, Deborah A O'Neil
Jan 1, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Emmanuel Edwar SiddigAhmed Hassan Fahal
Jan 16, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Emmanuel Edwar SiddigAhmed Hassan Fahal
Jan 16, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Antonella SantonaAhmed Hassan Fahal
Jan 29, 2021·BMJ Case Reports·Anuj Kumar SharmaKumar Rajesh Ranjan
Jan 1, 2018·Anais Brasileiros De Dermatologia·Carmelia Matos Santiago Reis, Eugenio Galdino de Mendonça Reis-Filho
Dec 11, 2020·Journal of Clinical Microbiology·Bertrand NyuykongeCorné H W Klaassen
May 14, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Hassan H MusaIdriss H Musa
Aug 12, 2020·Journal of the American Podiatric Medical Association·Montserrat ArceuXimena Wortsman
Jun 18, 2021·JAAD Case Reports·Uros RakitaAleksandar L Krunic
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdelhalim B MahmoudPascal Mäser
Sep 25, 2021·BMC Infectious Diseases·Ammar AwadHussam S Khougali

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