PMID: 8942380Sep 1, 1996Paper

Euphorbia sap keratopathy: four cases and a possible pathogenic mechanism

The British Journal of Ophthalmology
I U Scott, C L Karp

Abstract

To report four cases of Euphorbia sap causing anterior segment toxicity. Medical records of four patients who presented with Euphorbia sap keratoconjunctivitis were reviewed. Clinical findings were compared with previously published reports. All of these patients experienced a similar clinical course. Initial contact with Euphorbia sap caused punctate epitheliopathy; patients noted immediate burning and photophobia, but no visual loss. In all cases, patients experienced epithelial slough with delayed healing, requiring approximately 9 days to heal the epithelial defect. Patients were treated with topical antibiotics, pressure patching or a bandage contact lens, and final visual acuities were excellent in all cases. A review of the literature revealed that Euphorbia sap contains a diterpenoid diester which exhibits antineoplastic activity in rodents. Individuals who work with Euphorbia plants should be cautioned to wear eye protection. Patients with Euphorbia sap anterior segment toxicity should be informed that their condition may worsen initially, but that visual outcome is generally excellent. The progressive corneal epithelial sloughing and delayed corneal epithelial healing may be secondary to the antineoplastic effects of ...Continue Reading

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Citations

Nov 12, 2005·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·S MennelC H Meyer
Jun 27, 2007·Cornea·Rohan MeraniKathy A McClellan
Jul 4, 2009·Indian Journal of Ophthalmology·Samar K BasakSoham Basak
Mar 26, 2013·International Ophthalmology·Yasin CinarAlparslan Sahin
Jul 1, 2008·Medical Journal, Armed Forces India·D Joshi, P Shingal
Jul 7, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A Fernandez-ArcheM D Garcia
Nov 3, 2007·The Journal of Emergency Medicine·Gil Z ShlamovitzJorge A Diaz
Dec 4, 2019·Eye & Contact Lens·Adam K CohenAnat Galor
Aug 7, 2021·Journal français d'ophtalmologie·T Ferreira de MouraA Denoyer

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