Euploidy in relation to blastocyst sex and morphology

Journal of Assisted Reproduction and Genetics
Ange WangLynn M Westphal

Abstract

The objective of our study is to assess the relationship of embryo ploidy status in relation to embryo sex, morphological characteristics, and transfer parameters. This is a retrospective cohort study at an academic medical center of patients who underwent in vitro fertilization with preimplantation genetic screening (PGS) from 2010 to 2015. Embryos were screened with 24-chromosome preimplantation genetic screening with day 5/6 trophectoderm biopsy. We investigated embryo euploidy in relation to morphology (expansion, inner cell mass, trophectoderm), embryo sex, biopsy day, and blastocyst cohort size. We used multivariate logistic regression to calculate odds ratios of euploidy in relation to these parameters. A total of 1559 embryos from 316 cycles and 233 patients (mean maternal age = 37.8 ± 4.2 years) were included in the analysis. Six hundred and twenty-eight blastocysts (40.3%) were found to be euploid. Expansion (p < 0.001), inner cell mass (ICM) (p < 0.01), and trophectoderm grade (p < 0.001) were significantly associated with embryo ploidy in bivariate models controlling for maternal age, while embryo sex, biopsy day, and blastocyst cohort size were not associated with embryo ploidy. In a multivariate model, we found th...Continue Reading

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Citations

Sep 9, 2019·Journal of Assisted Reproduction and Genetics·Yi GuoLiying Liu
Aug 21, 2020·Human Fertility : Journal of the British Fertility Society·Marcos Iuri Roos KulmannNilo Frantz
Aug 19, 2020·Archives of Gynecology and Obstetrics·Katherine E McDanielAli Ahmady
Jun 17, 2020·Human Fertility : Journal of the British Fertility Society·Caizhu WangHong Zhou
Feb 8, 2021·Reproductive Biomedicine Online·Guvenc KarlıkayaMustafa Bahceci
May 20, 2021·Journal of Assisted Reproduction and Genetics·Marcos Iuri Roos KulmannNilo Frantz
Jun 5, 2021·Journal of Assisted Reproduction and Genetics·Christopher P MoutosJohn R Crochet

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