Eupnea of in situ rats persists following blockers of in vitro pacemaker burster activities.

Respiratory Physiology & Neurobiology
Walter M St-John

Abstract

Two groups of intrinsically bursting neurons, linked to respiration, have been identified using in vitro medullary slice preparations. One group is dependent upon a calcium-activated nonspecific cationic current that is blocked by flufanemic acid. This group is hypothesized as essential for eupnea, but not gasping. The second group is dependent upon conductance through persistent sodium channels that is blocked by riluzole. This group is proposed to underlie both eupnea and gasping. In the decerebrate in situ preparation of the juvenile rat, flufanemic acid caused an increase in frequency and a decrease in peak level of the phrenic and vagus nerve activities in both eupnea and gasping. Similar changes in eupnea followed the simultaneous blockades by flufanemic acid and riluzole. However, gasping was eliminated. These results do not support the hypothesis that conductances through either persistent sodium channels or calcium-activated nonspecific cationic channels are essential for the neurogenesis of eupnea. However, gasping does depend upon a conductance through persistent sodium channels.

References

Sep 29, 2000·Respiration Physiology·W M St-John, J F Paton
Jun 21, 2005·Respiratory Physiology & Neurobiology·Jan-Marino Ramirez, Jean-Charles Viemari
Feb 14, 2006·Nature Neuroscience·Julian F R PatonWalter M St-John
Aug 12, 2006·Respiratory Physiology & Neurobiology·Walter M St-JohnJulian F R Paton
Feb 6, 2007·Neuroscience Letters·Fernando Peña, Miguel-Angel Aguileta

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Citations

Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Walter M St John
Nov 6, 2012·Annual Review of Physiology·Jack L FeldmanPaul A Gray
Jun 15, 2010·Journal of Computational Neuroscience·Amit LalMakio Ishiguro
Apr 3, 2013·Respiratory Physiology & Neurobiology·Michael George Zaki Ghali, Vitaliy Marchenko
Jan 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B M GajdaW K Milsom

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