Euro-Collins solution exacerbates lung injury in the setting of high-flow reperfusion

The Journal of Thoracic and Cardiovascular Surgery
N F DeLimaI L Kron

Abstract

Single-lung transplantation has been abandoned for the treatment of pulmonary hypertension by many centers because of overperfusion of the graft following implantation. Euro-Collins solution is currently used for lung preservation despite the vasoconstrictive effect of this intracellular-type solution. We hypothesized that high-flow reperfusion, alone or in combination with Euro-Collins-induced vasoconstriction, may cause lung dysfunction. Twenty-eight New Zealand White rabbit lungs were harvested and studied in an isolated, blood-perfused model of lung function after 4 hours of cold ischemia. Control lungs were preserved with 50 ml/kg cold saline solution flush and reperfused at either normal flow (60 ml/min) or high flow (120 ml/min). Experimental lungs were preserved with 50 ml/kg cold Euro-Collins solution and reperfused at normal or high flow rates. The arteriovenous oxygen gradient at the end of the 30-minute reperfusion period was significantly lower in the high-flow versus the low-flow experimental group (31.1 +/- 4.2 vs 130.6 +/- 41.6 mm Hg, p < 0.05). The pulmonary vascular resistance was increased in the high-flow groups and the experimental groups, with a statistically significant difference between low-flow experim...Continue Reading

Citations

Mar 1, 1996·The Annals of Thoracic Surgery·N F DeLimaI L Kron
Feb 10, 1998·The Annals of Thoracic Surgery·M S BhabraT L Hooper
Jul 1, 1996·The Annals of Thoracic Surgery·M C MauneyC G Tribble
Sep 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·O A BinnsI L Kron
Oct 6, 1997·The Annals of Thoracic Surgery·R C KingI L Kron
Mar 26, 1999·The Journal of Surgical Research·A FehrenbachJ Richter
Dec 29, 2000·The Journal of Laboratory and Clinical Medicine·R F Kelly
Dec 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·O A BinnsI L Kron
May 7, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Lingfeng XuBingyang Ji

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