Euroconference on the Biology of Type IV Secretion Processes: bacterial gates into the outer world

Molecular Microbiology
Matxalen Llosa, David O'Callaghan

Abstract

Type IV secretion systems (T4SSs) mediate both protein and ssDNA secretion from a wide range of bacteria into virtually any cell type or into the milieu. It is this versatility that confers on them the ability to participate in many processes of bacterial life that imply communication with their environment. Type IV secretion systems are involved in horizontal DNA transfer to other bacteria and to plant cells, in DNA uptake from the milieu, in toxin secretion into the milieu, and in the injection of virulence factors into the eukaryotic host cell in a number of mammalian and plant pathogens. Recently, a EuroConference addressed the different aspects of the biology of these transmembrane multiprotein complexes, from the crystal structure of the individual components to the modification that the secreted substrates induce in the recipient cell. Significant progress has been made in the understanding of the molecular architecture and mechanism of secretion. The analysis of protein-protein interactions confirms the role of coupling proteins as substrate recruiters for the transporter. The VirB10 component of the complex has come up as a strong candidate for signal transducer. The wide range of effects on the recipient suggests that...Continue Reading

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Citations

Jun 1, 2005·Trends in Microbiology·Jianxiong LiTzvi Tzfira
Nov 20, 2004·Nature Reviews. Microbiology·Jacques BatutDavid O'Callaghan
Jul 17, 2007·Journal of Bacteriology·John ZupanPatricia Zambryski
Feb 9, 2010·Journal of Bacteriology·Wilmara Salgado-PabónJoseph P Dillard
Jun 22, 2005·Journal of Bacteriology·Maria KostakiotiChristos Stathopoulos
Mar 4, 2005·Journal of Bacteriology·Youfu ZhaoGeorge W Sundin
Sep 13, 2005·Annual Review of Microbiology·Peter J ChristieEric Cascales
Dec 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Eric Cascales, Peter J Christie
Jan 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Annette C VergunstPaul J J Hooykaas
Jun 11, 2009·Molecular Microbiology·Matxalen LlosaChristoph Dehio
Jan 8, 2005·Research in Microbiology·Matxalen Llosa, Fernando de la Cruz
Feb 14, 2006·Pathologie-biologie·J-P LavigneD O'Callaghan
May 20, 2005·The Journal of Biological Chemistry·Qing YuanChristian Baron
Aug 12, 2005·Molecular Membrane Biology·Peter J Christie, Eric Cascales

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