PMID: 9128940May 16, 1997Paper

European collaborative research on mosaicism in CVS (EUCROMIC)--fetal and extrafetal cell lineages in 192 gestations with CVS mosaicism involving single autosomal trisomy

American Journal of Medical Genetics
J M Hahnemann, L O Vejerslev

Abstract

Cytogenetic information on cells from cytotrophoblast, villus mesenchyme, and one or more fetal tissues was available for 192 gestations with mosaicism or non-mosaic fetoplacental discrepancy involving a single autosomal trisomy in the chorionic villus sample (CVS), registered in a collaborative study (EUCROMIC) during the period 1986-1994. In order to identify predictors of confined placental mosaicism (CPM), generalized mosaicism and/or uniparental disomy (UPD), distribution of the mosaic and nonmosaic aneuploid cell lines in the different fetal and extrafetal cell lineages were analyzed. Data were related to existing hypotheses on mechanisms leading to fetoplacental discrepancies and early extraembryonic cell differentiation. Trisomy 21 mosaicism was the one most frequently confirmed in the fetus. Non-mosaic trisomy 13, 18, and 21 in the villus mesenchyme indicated the presence of a trisomic cell line in the fetus proper. Non-mosaic trisomy 2, 7, and 16 in villus mesenchyme was always found with concomitant mosaic or non-mosaic trisomy in the cytotrophoblast, but was never recovered in the fetus. Mosaic trisomy 3, 7, and 20 was predominantly restricted to the cytotrophoblast, mosaic trisomy 2 to the villus mesenchyme. Trisom...Continue Reading

References

May 1, 1992·Prenatal Diagnosis·D H LedbetterK L Copeland
Aug 1, 1994·Prenatal Diagnosis·J VaughanG Moore
Feb 1, 1995·Prenatal Diagnosis·J Wolstenholme
Mar 1, 1994·Journal of Medical Genetics·C J EnglishJ Wolstenholme
Nov 1, 1995·Journal of Medical Genetics·S LangloisD K Kalousek

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Citations

Mar 29, 2014·Human Reproduction Update·Tyl H TaylorDarren K Griffin
Apr 9, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·V S Lestou, D K Kalousek
Jun 3, 2009·Stem Cells and Development·Dusko IlicAna Krtolica
Jan 19, 2006·European Journal of Human Genetics : EJHG·Francesca R GratiGiuseppe Simoni
Mar 16, 2013·Genetics in Medicine : Official Journal of the American College of Medical Genetics·April L HallGail H Vance
Mar 6, 2008·Human Reproduction·B C JacodUNKNOWN IVF-CPM Study Group
Jan 1, 2014·Journal of Clinical Medicine·Francesca Romana Grati
Jan 1, 2014·Journal of Clinical Medicine·Paula JorgeAna Maria Fortuna
Nov 29, 2011·Clinics in Laboratory Medicine·Colleen Jackson-Cook
Feb 15, 2011·Gynécologie, obstétrique & fertilité·C Labeau-GaüzereJ Toutain
Apr 11, 2009·Homeopathy : the Journal of the Faculty of Homeopathy·Trevor D B Thompson, Elizabeth A Thompson
Oct 20, 2005·Acta Obstetricia Et Gynecologica Scandinavica·Elisabeth LjungerGöran Annerén
Sep 21, 2011·American Journal of Medical Genetics. Part a·Daniela TurchettiMarco Seri
Mar 21, 2013·American Journal of Medical Genetics. Part a·Femke A T de VriesDiane Van Opstal
Nov 22, 2012·Prenatal Diagnosis·Yvonne K Y ChengKwong Wai Choy
Mar 19, 2014·Prenatal Diagnosis·Paola BattagliaMaria Carla Pittalis
Aug 20, 2015·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Susannah MaxwellPeter O'Leary
Mar 6, 2002·Seminars in Perinatology·Ronald J Wapner, Dawnette Lewis
Apr 14, 2015·Clinical Genetics·P BradyJ R Vermeesch
Jun 5, 2016·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Craig M ZeligPeter G Napolitano
Aug 19, 2016·Prenatal Diagnosis·Merlin G Butler
Sep 8, 2016·Archives of Toxicology·Claudia GundackerMarkus Hengstschläger
Feb 11, 2015·Scientific Reports·Laura KasakMaris Laan
Jun 28, 2017·American Journal of Medical Genetics. Part a·Andrew M ReittingerSamantha A Schrier Vergano
Mar 13, 2017·Best Practice & Research. Clinical Obstetrics & Gynaecology·Francesca Romana GratiGiuseppe Simoni
Mar 4, 1998·Prenatal Diagnosis·M B DelatyckiR J Gardner
Feb 2, 2018·Prenatal Diagnosis·Nathalie BrisonJoris R Vermeesch
Nov 10, 2017·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Diane Van OpstalErik A Sistermans
Feb 12, 2011·Cytogenetic and Genome Research·I Lebedev
Jul 9, 2014·Obstetrics and Gynecology·Eugene PergamentMatthew Rabinowitz
Dec 13, 2002·Prenatal Diagnosis·Dorothy Warburton

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