PMID: 6140202Feb 1, 1984

European Cooperative Crohn's Disease Study (ECCDS): results of drug treatment

H MalchowH Jesdinsky


A multicenter double-blind study of the effectiveness of sulfasalazine and 6-methylprednisolone, alone and in combination, was conducted on 452 patients with Crohn's disease. One hundred sixty patients were previously untreated; 292 patients were previously treated. The Crohn's disease activity index (CDAI) was used to determine whether a patient had active (CDAI greater than or equal to 150, n = 215) or quiescent disease (CDAI less than 150, n = 237). Treatment of active disease consisted of high-dose 6-methylprednisolone, 6-methylprednisolone combined with 3 g of sulfasalazine, 3 g of sulfasalazine alone, or placebo, and lasted 6 wk. Patients in remission received maintenance doses of one of these drug regimens for periods of up to 2 yr. One hundred ninety-two patients completed the 2-yr study period. Results were evaluated using life-table analysis and outcome ranking. These methods showed 6-methylprednisolone to be the most effective drug in overall comparison of all patients (p less than 0.001); in previously treated patients (p less than 0.001); and in subgroups: active disease (p less than 0.001), only small bowel disease (p less than 0.05), and both small bowel and colon disease (p less than 0.05). Combination of 6-meth...Continue Reading


Dec 8, 2011·Digestive Diseases and Sciences·Jan Hendrik NiessGeorg B T von Boyen
Apr 1, 1995·Gastroenterology·A GriffithsL R Sutherland
Jun 1, 1994·Baillière's Clinical Gastroenterology·A T Cole, C J Hawkey
Mar 20, 1998·Advances in Internal Medicine·S J Bickston, F Cominelli
Nov 18, 2000·Lancet·S NikolausS Schreiber
Jul 27, 1985·Lancet·V A JonesJ O Hunter
Nov 26, 1998·Clinical Therapeutics·Stephen B HanauerM G Vreeland
Dec 5, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·A LamprechtC M Lehr
Oct 25, 2003·Journal of the American Academy of Dermatology·M R van de ScheurI van der Waal
Jun 18, 1999·Gastroenterology Clinics of North America·R B Stein, Stephen B Hanauer
Jun 18, 1999·Gastroenterology Clinics of North America·P Michetti, M A Peppercorn
Mar 6, 2008·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·P K Rao DhruvaJ Torkington
Apr 5, 2003·Best Practice & Research. Clinical Gastroenterology·Barbara Désir, Ernest G Seidman
Sep 1, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A QasimC O'Morain
Jul 23, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S ArdizzoneG Bianchi Porro
Oct 18, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S ArdizzoneG Bianchi Porro
Jan 1, 1991·Annals of Surgery·S PostC Herfarth
Aug 30, 2007·Journal of Gastroenterology and Hepatology·Yusuf ErzinAykut Ferhat Celik
Nov 26, 2009·Journal of Gastroenterology and Hepatology·Joseph J Y SungP Marteau
Aug 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·N Tvede, J Brynskov
Jul 8, 2005·Journal of Clinical Microbiology·Alexander SwidsinskiH Lochs
May 4, 2007·Archives of Disease in Childhood·A F RodriguesM S Murphy
Aug 13, 2004·Gut·M J CarterIBD Section, British Society of Gastroenterology
Feb 17, 2006·Gut·S P TravisEuropean Crohn's and Colitis Organisation
Jun 1, 1991·Gut·M C de KaskiH Hodgson
Oct 1, 1988·Postgraduate Medical Journal·R N Allan
Jun 23, 2011·Therapeutic Advances in Gastroenterology·Marietta Iacucci, Subrata Ghosh
Oct 15, 2008·BioPsychoSocial Medicine·Hans-Christian DeterGerman Study Group on Psychosocial Intervention in Crohn's Disease
May 8, 2008·World Journal of Gastroenterology : WJG·Amandeep K Shergill, Jonathan P Terdiman
Jan 18, 2008·World Journal of Gastroenterology : WJG·Patricia L Kozuch, Stephen B Hanauer
Jul 19, 2008·World Journal of Gastroenterology : WJG·Hugh-J Freeman
Feb 21, 2008·World Journal of Gastroenterology : WJG·Hugh James Freeman
Mar 27, 2009·World Journal of Gastroenterology : WJG·Giovanni-C ActisFloriano Rosina
Nov 26, 2009·World Journal of Gastroenterology : WJG·Tatiana Sofía Rodríguez-ReynaJesús Kazúo Yamamoto-Furusho
Mar 25, 2010·World Journal of Gastroenterology : WJG·Nirooshun Rajendran, Devinder Kumar
Apr 17, 2010·World Journal of Gastroenterology : WJG·Hugh James Freeman
Apr 30, 2011·World Journal of Gastroenterology : WJG·Paolo GionchettiFernando Rizzello
Sep 24, 2011·World Journal of Gastroenterology : WJG·Javier P GisbertF Gomollón
May 4, 2012·World Journal of Gastroenterology : WJG·Øistein Hovde, B Moum
May 21, 2014·Journal of Crohn's & Colitis·Pieter HindryckxClinical Trial Committee Clincom of the European Crohn's and Colitis Organisation (ECCO)
Jul 13, 2012·Journal of Crohn's & Colitis·Tiago NunesMiquel Sans
Dec 3, 2010·Journal of Crohn's & Colitis·Axel U DignassEuropean Crohn's and Colitis Organisation (ECCO)
Sep 1, 2000·European Journal of Internal Medicine·B Moum
Jun 1, 1994·Baillière's Clinical Gastroenterology·S P Travis, D P Jewell
Feb 24, 2001·The Surgical Clinics of North America·R B Stein, G R Lichtenstein
Dec 2, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·R CaprilliM Zippi
Jul 3, 2007·Seminars in Pediatric Surgery·Ryan Carvalho, Jeffrey S Hyams
Sep 29, 2009·European Journal of Internal Medicine·Sara RennaMario Cottone
Feb 7, 2013·Best Practice & Research. Clinical Gastroenterology·Charles RandallGregory Constantine
Jun 11, 2014·Best Practice & Research. Clinical Gastroenterology·Peter M Irving
Jun 5, 2004·Gastroenterology Clinics of North America·Laura E Harrell, Stephen B Hanauer
Mar 31, 2001·The American Journal of Gastroenterology·E RicartW J Sandborn
Jun 5, 2004·Gastroenterology Clinics of North America·Sonia Friedman

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