European multicenter trial of the prevention of cystoid macular edema after cataract surgery in nondiabetics: ESCRS PREMED study report 1

Journal of Cataract and Refractive Surgery
Laura H P WieldersESCRS PREMED Study Group

Abstract

To compare the efficacy of a topical nonsteroidal antiinflammatory drug, topical corticosteroid, and a combination of both drugs to prevent the occurrence of cystoid macular edema (CME) after cataract surgery in nondiabetic patients. Twelve European study centers. Randomized clinical trial. Nondiabetic patients having uneventful cataract surgery were included in this study. Patients were randomized to receive topical bromfenac 0.09% twice daily for 2 weeks or dexamethasone 0.1% 4 times daily with 1 drop less per day every following week, or a combination of both. The primary outcome was the difference in central subfield mean macular thickness 6 weeks postoperatively. Secondary outcome measures included corrected distance visual acuity as well as the incidence of CME and clinically significant macular edema (CSME) within 6 weeks and 12 weeks postoperatively. This study comprised 914 patients. Six weeks postoperatively, the central subfield mean macular thickness was 288.3 μm, 296.0 μm, and 284.5 μm in the bromfenac group, dexamethasone group, and combination treatment group, respectively (overall P = .006). The incidence of clinically significant macular edema within 12 weeks postoperatively was 3.6%, 5.1%, and 1.5%, respective...Continue Reading

Associated Clinical Trials

References

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Citations

Sep 12, 2018·European Journal of Ophthalmology·Shahenda A El GharbawyMoataz Hamed Osman
Jan 8, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Alejandro Gonzalez-De la RosaArturo Santos
Apr 7, 2019·Clinical & Experimental Ophthalmology·Jina V HanCharles Nj McGhee
Jul 26, 2019·Expert Opinion on Pharmacotherapy·Scott M WentzThomas Ciulla
Sep 6, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Alejandro Gonzalez-De la RosaArturo Santos
Dec 24, 2018·Journal of Cataract and Refractive Surgery·William G Myers
Jul 30, 2018·Journal of Cataract and Refractive Surgery·Thomas Kohnen
Sep 1, 2018·Journal of Cataract and Refractive Surgery·Michele De MariaLuigi Fontana
Aug 18, 2018·Journal of Cataract and Refractive Surgery·Sabyasachi Sengupta
Feb 13, 2020·Journal of Cataract and Refractive Surgery·Keith WalterUNKNOWN Wake Forest School of Medicine
Apr 30, 2020·Retina·Sergio CopeteMiguel A Zapata
Sep 25, 2020·Journal of Clinical Medicine·Alexander AaronsonRaimo Tuuminen
Dec 24, 2018·Acta Ophthalmologica·Claudia TaipaleRaimo Tuuminen
Dec 21, 2019·Journal of Cataract and Refractive Surgery·Andrzej Grzybowski, Piotr Kanclerz
Jun 25, 2020·International Ophthalmology Clinics·Ella H Leung, Janet H Leung
Oct 6, 2020·Therapeutic Advances in Ophthalmology·Carlo CaginiMarco Messina
Dec 21, 2019·Journal of Cataract and Refractive Surgery·Sophie Bryde LaursenLine Kessel
Oct 24, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Andrzej GrzybowskiUwe Pleyer
Oct 8, 2020·Current Opinion in Ophthalmology·Kerry K AssilMichael H Goldstein
Sep 15, 2020·Journal of Cataract and Refractive Surgery
Sep 15, 2020·Journal of Cataract and Refractive Surgery·Lewis M LevitzStephen J Kim
Jan 26, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Nisa SilvaAngelina Meireles
Jan 2, 2021·Translational Vision Science & Technology·Christian J F BertensMarlies Gijs
Oct 4, 2020·Journal of Cataract and Refractive Surgery·Rob W P SimonsUNKNOWN ESCRS PREMED Study Group
Oct 22, 2020·Journal of Cataract and Refractive Surgery·Jesper H ErichsenLine Kessel
Dec 2, 2020·Journal of Cataract and Refractive Surgery
Dec 5, 2020·Current Opinion in Ophthalmology·Kerry K AssilMichael H Goldstein
May 22, 2021·Journal of Cataract and Refractive Surgery·Imran H YusufAlexander C Day
May 22, 2021·Journal of Cataract and Refractive Surgery·Jesper H ErichsenLine Kessel

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