European multicentre study validates enhanced liver fibrosis test as biomarker of fibrosis in systemic sclerosis

Rheumatology
Giuseppina AbignanoFrancesco Del Galdo

Abstract

To validate enhanced liver fibrosis (ELF) test and its components-amino-terminal propeptide of procollagen type III (PIIINP), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and HA-as biomarkers of fibrosis in SSc in an independent, international, multicentre cohort. Two hundred and fifty-four SSc patients from six Rheumatology Centres were included. Sera were collected and stored according to EUSTAR biobanking recommendations and analysed through automated high throughput diagnostics. Statistical analysis was performed with SPSS software. Two hundred and forty-seven SSc patients (mean age 55.7 ± 13.9 years, 202 F) were analysed. ELF score, TIMP-1 and PIIINP levels were higher in males (P = 0.0197, P = 0.0107, P = 0.0108 respectively) and in dcSSc (P = 0.001, P = 0.0008, P < 0.0001 respectively). ELF score and the single markers significantly correlated with modified Rodnan skin score (r = 0.37, P < 0.0001), disease activity and severity (P < 0.0001 for all markers, except for HA P = 0.0001) and inversely with forced vital capacity, (FVC) % (TIMP-1, r = -0.21, P = 0.0012; PIIINP, r = -0.26, P = 0.0001), TLC% (ELF score, r = -0.20, P = 0.0036; TIMP-1, r = -0.32, P < 0.0001; PIIINP, r = -0.28, P < 0.0001), diffusion capac...Continue Reading

References

Jun 18, 2003·European Radiology·Marjolein DrentJohny A Verschakelen
Dec 4, 2004·Gastroenterology·William M C RosenbergUNKNOWN European Liver Fibrosis Group
Sep 9, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Metin AytekinRaed A Dweik
Nov 4, 2010·Current Rheumatology Reports·Giuseppina AbignanoFrancesco Del Galdo
Feb 3, 2011·Annals of the Rheumatic Diseases·Christian BeyerUNKNOWN EUSTAR Biobanking Group
Mar 21, 2013·Annals of the Rheumatic Diseases·Giuseppina AbignanoFrancesco Del Galdo
Jan 21, 2014·Current Rheumatology Reports·Giuseppina Abignano, Francesco Del Galdo

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