European Myeloma Network recommendations on tools for the diagnosis and monitoring of multiple myeloma: what to use and when

Haematologica
Jo CaersMonika Engelhardt

Abstract

The diagnosis of multiple myeloma can be challenging, even for experienced physicians, and requires close collaboration between numerous disciplines (orthopedics, radiology, nuclear medicine, radiation therapy, hematology and oncology) before the final diagnosis of myeloma is made. The definition of multiple myeloma is based on the presence of clinical, biochemical, histopathological, and radiological markers of disease. Specific tests are needed both at presentation and during follow-up in order to reach the correct diagnosis and characterize the disease precisely. These tests can also serve prognostic purposes and are useful for follow-up of myeloma patients. Molecular analyses remain pivotal for defining high-risk myeloma and are used in updated patient stratifications, while minimal residual disease assessment via flow cytometry, molecular techniques and radiological approaches provides additional prognostic information on patients' long-term outcome. This pivotal information will guide our future treatment decisions in forthcoming clinical trials. The European Myeloma Network group updated their guidelines on different diagnostic recommendations, which should be of value to enable appropriate use of the recommendations bot...Continue Reading

Citations

May 11, 2019·American Journal of Hematology·Rafael AlonsoJoaquín Martínez-López
Mar 5, 2020·Zeitschrift für Gerontologie und Geriatrie·Valentin Goede
Sep 17, 2020·American Journal of Hematology·Maurus LocherNormann Steiner
May 28, 2020·Frontiers in Immunology·Margaux LejeuneJo Caers
Feb 1, 2021·Lancet·Niels W C J van de DonkKwee L Yong
Feb 8, 2021·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M A DimopoulosUNKNOWN ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Jan 1, 2021·Medicina·Liliana BelgioiaRenzo Corvò
Feb 18, 2021·Expert Review of Molecular Diagnostics·Federica Zito MarinoRenato Franco
May 1, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gian Maria ZaccariaFrancesca Gay
Feb 4, 2022·European Journal of Haematology·Michael T GundesenUNKNOWN Nordic Myeloma Study Group

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Methods Mentioned

BETA
electrophoresis
urine collection
urine collections
biopsy
flow cytometry
imaging technique
protein collection
ISS
PCR

Software Mentioned

IMAJEM
EuroFlow

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