European Organization for the Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG) host factors and invasive fungal infections in patients with haematological malignancies

The Journal of Antimicrobial Chemotherapy
Martin HoeniglRobert Krause

Abstract

Fulfilment of host factors defined by the revised European Organization for the Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG) criteria is required for establishing the diagnosis of possible or probable invasive fungal infection (IFI). This case-control study evaluates EORTC/MSG host factors among patients with haematological malignancies. Fifty-eight patients with haematological malignancies who developed probable (n = 38) or proven (n = 20) IFI over a 5 year period were retrospectively evaluated regarding EORTC/MSG host factors. Results were compared with those obtained from patients with haematological malignancies who did not develop IFI (116 patients who received systemic antifungal prophylaxis or empirical therapy and 116 patients who did not; all data collected in 2010). Fourteen patients had invasive yeast infection and 44 patients had invasive mould infection (IMI). Prolonged neutropenia (35/58, 60% versus 29/116, 25%), prolonged systemic corticosteroid (cut-off 21 days: 13/58, 22% versus 6/116, 5%; cut-off 14 days: 18/58, 31% versus 9/116, 8%) and T cell suppressive therapy (35/44, 80% versus 69/116, 59%) were significantly associated with development of IFI/IMI in our cohort. Previous allogeneic ste...Continue Reading

References

Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S AsciogluUNKNOWN Mycoses Study Group of the National Institute of Allergy and Infectious Diseases
May 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ben De PauwUNKNOWN National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
Aug 14, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Z ErjavecP E Verweij
Jun 22, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Martin HoeniglRobert Krause
Jan 5, 2011·The Journal of Antimicrobial Chemotherapy·Samir AgrawalChristopher Kibbler
Jan 5, 2011·The Journal of Antimicrobial Chemotherapy·Livio PaganoNicole Blijlevens

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Citations

Mar 20, 2013·Current Opinion in Pulmonary Medicine·Gauri Godbole, Vanya Gant
Sep 10, 2014·American Journal of Respiratory and Critical Care Medicine·Juergen PrattesMartin Hoenigl
Jul 9, 2013·Critical Care Clinics·Eric J Bow
Jul 1, 2016·Current Fungal Infection Reports·Juergen PrattesMartin Hoenigl
Mar 19, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·F M J ReischiesM Hoenigl
Dec 25, 2015·Journal of Clinical Microbiology·Frederike M J ReischiesMartin Hoenigl
Mar 26, 2019·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Igor StomaVeronika Cherniak
Jun 6, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Variya NganthaveePloyploen Phikulsod
Aug 15, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Andreas TrobischV Strenger
Aug 4, 2020·Mycoses·Jeffrey D JenksMartin Hoenigl
Jul 7, 2017·Current Fungal Infection Reports·Sven Heldt, Martin Hoenigl
Apr 22, 2017·Medical Mycology·Juergen PrattesInes Zollner-Schwetz
Oct 8, 2017·Der Internist·H J F SalzerM Hönigl

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