European propolis is highly active against trypanosomatids including Crithidia fasciculata

Scientific Reports
Abdullah AlotaibiDavid G Watson

Abstract

Extracts of 35 samples of European propolis were tested against wild type and resistant strains of the protozoal pathogens Trypanosoma brucei, Trypanosoma congolense and Leishmania mexicana. The extracts were also tested against Crithidia fasciculata a close relative of Crithidia mellificae, a parasite of bees. Crithidia, Trypanosoma and Leishmania are all members of the order Kinetoplastida. High levels of activity were obtained for all the samples with the levels of activity varying across the sample set. The highest levels of activity were found against L. mexicana. The propolis samples were profiled by using liquid chromatography with high resolution mass spectrometry (LC-MS) and principal components analysis (PCA) of the data obtained indicated there was a wide variation in the composition of the propolis samples. Orthogonal partial least squares (OPLS) associated a butyrate ester of pinobanksin with high activity against T. brucei whereas in the case of T. congolense high activity was associated with methyl ethers of chrysin and pinobanksin. In the case of C. fasciculata highest activity was associated with methyl ethers of galangin and pinobanksin. OPLS modelling of the activities against L. mexicana using the mass spect...Continue Reading

References

Apr 1, 2000·Molecular and Biochemical Parasitology·H P de KoningS M Jarvis
Aug 18, 2004·Phytochemical Analysis : PCA·Milena PopovaStefan Bogdanov
Apr 20, 2006·Experimental Parasitology·Simon GudinHarry P de Koning
Jun 24, 2008·Phytotherapy Research : PTR·Véronique SeidelJames Fearnley
Jan 16, 2010·Phytotherapy Research : PTR·Raghavendra RaghukumarVéronique Seidel
Apr 6, 2012·PloS One·Michael D Simone-Finstrom, Marla Spivak
Jul 22, 2014·Phytotherapy Research : PTR·Weam SiheriDavid G Watson
May 29, 2015·PLoS Pathogens·Benjamin P HurrellFabienne Tacchini-Cottier
Jul 7, 2015·Journal of Invertebrate Pathology·Jorgen RavoetDirk C de Graaf
Oct 10, 2015·The Journal of Experimental Biology·Renata S BorbaMarla Spivak
Dec 15, 2015·Phytochemical Analysis : PCA·Ruwida M K OmarDavid G Watson
Oct 11, 2016·Parasitology·Federica GiordaniMichael P Barrett
May 5, 2017·Insects·Michael Simone-FinstromMarla Spivak
Jul 28, 2018·Phytochemistry·Vassya BankovaBoryana Trusheva
Aug 17, 2018·The Journal of Physical Chemistry Letters·Michael FilatovKwang S Kim
Nov 19, 2018·Journal of Invertebrate Pathology·Loreley CastelliKarina Antúnez
Dec 22, 2017·Emerging Topics in Life Sciences·Harry P de Koning

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Citations

Nov 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Godwin U EbilomaHarry P De Koning
Jan 23, 2021·RSC Medicinal Chemistry·Humera AhmedRoderick A M Williams
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Adullah AlotaibiDavid G Watson
Jul 8, 2021·Chemistry & Biodiversity·Lucas A de L PaulaLizandra G Magalhães

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Methods Mentioned

BETA
PCA
transgenic

Software Mentioned

OPLS
Prism
GraphPad
Simca P

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