European Society of Hypertension position paper on renal denervation 2018

Journal of Hypertension
Roland E SchmiederMembers of the ESH Working Group on Interventional Treatment of Hypertension

Abstract

: This ESH update was deemed necessary with the publication of new results of sham-controlled randomized blinded prospective trials with renal denervation (RDN). Proof of concept studies and first randomized trials (some were sham-controlled) displayed discrepant results about the efficacy of RDN. Three sham-controlled randomized trials of the 2.0 generation yielded now similarity in the average blood pressure decrease following RDN. Reduction of ambulatory blood pressure was approximately 5 to 7 mmHg and of office blood pressure 10 mmHg. Such a decrease in blood pressure by pharmacologic therapy has been found to be associated with lower incidence of cardiovascular events in particular with respect to heart failure and stroke by roughly 25%. Nevertheless, some questions about renal denervation are unanswered. The heterogeneity of the blood pressure-lowering response point to the clinical need to identify predictors for efficacy, and questions on long-term safety could not have been answered due to the short duration of the sham-controlled randomized clinical trials.

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Citations

Jun 18, 2019·Hypertension·Michael DoumasCostas Tsioufis
Jul 12, 2019·Heart·Melvin D LoboUNKNOWN British & Irish Hypertension Society, the British Cardiovascular Society, the British Cardiovascular Intervention Society, t
Apr 15, 2020·Nature Reviews. Cardiology·Lucas LauderFelix Mahfoud
Jan 15, 2019·Journal of Hypertension·Roland E Schmieder, Felix Mahfoud
Jan 15, 2019·Journal of Hypertension·Masayuki Tanemoto
Mar 14, 2020·Future Cardiology·Noman LateefSean Janzer
Mar 12, 2020·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Rosa Maria BrunoClaudio Ferri
Apr 4, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Roland E SchmiederChristian Ott
Nov 18, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Roland E Schmieder
Apr 2, 2021·Circulation Research·Felix MahfoudMelvin D Lobo
Apr 26, 2021·Hellenic Journal of Cardiology : HJC = Hellēnikē Kardiologikē Epitheōrēsē·Michael DoumasUNKNOWN Task Force of the Greek ESH Excellence centers
Apr 21, 2021·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Aluisio Andrade-LimaClaudia L M Forjaz
Nov 14, 2020·Current Opinion in Nephrology and Hypertension·Agnes Bosch, Roland E Schmieder
Aug 7, 2021·Expert Review of Cardiovascular Therapy·Márcio Galindo KiuchiMarkus P Schlaich
Jul 16, 2021·Journal of Hypertension·Roland E SchmiederUNKNOWN members of the ESH Working Group on Device-Based Treatment of Hypertension
Sep 26, 2021·Cardiovascular Research·Konstantinos P Tsioufis, Kyriakos Dimitriadis
Dec 17, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Roland E Schmieder, Agnes Bosch

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