European study of the efficacy of a cross-linked gel stent for the treatment of glaucoma.

Journal of Cataract and Refractive Surgery
Antonio M FeaFrancesco Oddone

Abstract

To investigate the efficacy and safety of a cross-linked gel stent (XEN45) with or without cataract surgery in the treatment of glaucoma patients. Five university hospitals. Prospective multicenter clinical trial. Patients with glaucoma inadequately controlled by treatment or poor compliance or intolerance to topical therapy were included. Patients were divided into those who had an implant only (Solo Group; phakic and pseudophakic patients) and those who had an implant combined with cataract surgery (Combo Group). Differences in mean intraocular pressure (IOP) and number of medications between the baseline preoperative visit and study end (12 months), and the rate of qualified and complete success, were evaluated. The Solo Group comprised 115 glaucoma patients (43 phakic and 72 pseudophakic) and the Combo Group comprised 56 patients. Compared with baseline, mean IOP (23.9 ± 7.6 to 15.5 ± 3.9) and number of medications (3.0 ± 1.1 to 0.5 ± 1.0) decreased significantly at 12-month follow-up (P < .001 for both). A >20% and >30% reduction in IOP from baseline was achieved by 72.3% and 52.6% of patients, respectively. IOP at 1 week postoperatively was a predictor of success, and the needling rate was inversely correlated with early ...Continue Reading

References

Feb 21, 2006·The British Journal of Ophthalmology·H A Quigley, A T Broman
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Mar 30, 2017·Journal of Ophthalmology·Ahmed GalalAmr Osman
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Jan 18, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Bettina HohbergerRobert Lämmer
Jan 23, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Randolf A WidderGernot Rössler
Sep 13, 2018·Eye·Neha MidhaKaweh Mansouri
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Citations

Dec 19, 2020·BMC Ophthalmology·Marc SchargusJan Darius Unterlauft
Jan 22, 2021·European Journal of Ophthalmology·Martina MenchiniMichele Figus
Apr 4, 2021·Journal of Clinical Medicine·Huub J PoelmanWishal D Ramdas
Apr 29, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Néstor Ventura-AbreuJosé María Martínez-de-la-Casa
Apr 29, 2021·European Journal of Ophthalmology·Néstor Ventura-AbreuMarta Pazos
Apr 30, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sheng Yang LimBryan Chin Hou Ang
May 1, 2021·Journal of Clinical Medicine·Antonio Maria FeaMichele Figus
May 4, 2021·European Journal of Ophthalmology·Itay E GabbaySimon Ruben
Aug 4, 2021·Scientific Reports·José M Martínez-de-la-CasaJulian García-Feijoo

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