PMID: 24506055Feb 11, 2014

Eurycoma longifolia in Radix for the treatment of ethanol-induced gastric lesion in rats

Pakistan Journal of Biological Sciences : PJBS
H M S Qodriyah, A Y Asmadi

Abstract

The effect of treatment with Radix on ethanol-induced gastric lesions was investigated. The main ingredient of Radix is Eurycoma longifolia. Twenty-four rats of the Sprague-Dawley species were randomly divided into four groups. Three groups were given 0.5 mL 100% ethanol orally. Another group was used as a control and was given only distilled water orally (control). After 6 h all the rats were fed with normal diet. One group that was administered with ethanol was only given distilled water orally (no treatment). Another two groups that were administered with ethanol were treated with oral Radix 0.128 mg g(-1) b.wt. (Radix) and oral ranitidine 21.4 mg kg(-1) b.wt. (Ranitidine), respectively. After one week, all the rats were fasted overnight and sacrificed. The stomach was isolated and examined for the presence and severity of gastric lesions. Measurements for malondialdehyde content and gastric acid concentration were also done. It is found that the ulcer index was lower in the Radix and ranitidine group compared to the no treatment group whereas in the control group there was no lesion. There was no difference in ulcer index between the Radix and ranitidine group. The gastric MDA content was significantly higher in all the gro...Continue Reading

References

Feb 1, 1976·The American Journal of Digestive Diseases·V P DinosoN S Murthy
Mar 28, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·A LedwozywA Kadziołka
Oct 16, 2008·World Journal of Gastroenterology : WJG·Jin-Shui PanJian-Lin Ren

Related Concepts

Ethanol
Anti-Ulcer Agent
Gastric Acid
Sodium Malondialdehyde
Phytotherapy
Plant Extracts
Pharmaceutical Plants
Zantic
Stomach
Gastric Ulcer

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