EUS-guided FNA biopsy of the muscularis propria of the antrum in patients with gastroparesis is feasible and safe

Gastrointestinal Endoscopy
Mohamed O OthmanR W McCallum

Abstract

EUS-guided FNA biopsies of the muscularis propria of the gastric wall in patients with gastroparesis could replace the routine use of surgical full-thickness biopsies for assessing the loss of the interstitial cells of Cajal (ICCs) and cellular infiltrates in the myenteric plexus. We investigated the efficacy and safety of EUS-guided FNA biopsies of the muscularis propria of the gastric antrum in gastroparesis and compared the tissue with a surgically obtained full-thickness biopsy specimen in the same patient. This was a prospective, nonrandomized, feasibility trial. Patients with gastroparesis who were undergoing gastric neurostimulator placement were enrolled. Patients had a gastric wall measurement by radial EUS in the body and antrum of the stomach followed by linear EUS examination and FNA of the muscularis propria in the antrum by using a 19-gauge core needle. Within 24 hours, a full-thickness biopsy specimen of the antrum was obtained surgically during neurostimulator placement. Endoscopic and surgical specimens were compared for tissue morphology, number of ICCs (c-kit stain) and enteric neurons (S-100 stain), and fibrosis (trichome) for each patient. The correlation coefficient of the ICC count per high-power field wa...Continue Reading

References

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Citations

Jan 17, 2016·Gastrointestinal Endoscopy·Madhusudan GroverPankaj J Pasricha
Aug 20, 2016·Autonomic Neuroscience : Basic & Clinical·William L HaslerRichard W McCallum
Jan 10, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M GroverUNKNOWN NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
Nov 30, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Brian R DavisRichard W McCallum
Oct 5, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Thomas L AbellPankaj J Pasricha
Oct 2, 2015·Journal of Neurogastroenterology and Motility·Mohammad Bashashati, Richard W McCallum
Aug 2, 2018·Current Opinion in Gastroenterology·Gulara Hajiyeva, Saowanee Ngamruengphong
Feb 2, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Thomas L AbellChristina Pinkston
Jul 29, 2020·Gastroenterology Clinics of North America·Lakshmikanth L ChikkamenahalliMadhusudan Grover

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