Eutectic mixture of local anaesthetics (EMLA®) as a primary dressing on painful chronic leg ulcers: a pilot randomised controlled trial

Pilot and Feasibility Studies
Anne PurcellAndrea P Marshall

Abstract

The physical, occupational, social and psychological impact of chronic leg ulcers (CLUs) on an individual is considerable. Wound-related pain (WRP), the most common symptom, is frequently reported as moderate to severe and mostly occurs at dressing change. WRP pain may not be alleviated by oral analgesics alone. Persistent poorly controlled leg ulcer pain can negatively impact wound healing and health-related quality of life (HRQoL). A pilot, parallel group, non-blinded, randomised controlled trial was conducted in six procedure clinics located in a public community nursing service in New South Wales, Australia to evaluate eutectic mixture of local anaesthetics (EMLA®) on painful CLUs when used as a primary dressing. The primary objective was to assess feasibility by using pre-determined criteria: at least 80% recruitment rate, 80% retention rate and 80% adherence to the study protocol. Key eligibility criteria were that participants had a painful CLU no larger than 100 cm2, a numerical rating scale (NRS) wound-related pain intensity score equal to or greater than 4, low to moderate exudate, no contraindications to EMLA® and capacity to consent. One hundred and seven patients with painful CLUs were screened for eligibility; 56%...Continue Reading

References

Apr 1, 1994·The Australian and New Zealand Journal of Surgery·S R Baker, M C Stacey
May 1, 2001·Journal of Advanced Nursing·E R Van TeijlingenW Graham
Jun 14, 2001·The Journal of Burn Care & Rehabilitation·E A KopeckyG Koren
Dec 12, 2001·Journal of Advanced Nursing·R Harris, E Dyson
Dec 18, 2001·Research in Nursing & Health·D Gross, L Fogg
Jun 18, 2002·Journal of the American Geriatrics Society·UNKNOWN AGS Panel on Persistent Pain in Older Persons
Sep 11, 2003·International Journal of Nursing Studies·Glenn GardnerSonya Osborne
Dec 4, 2003·Advances in Skin & Wound Care·Ian D GrahamAndrea Fisher
Feb 21, 2004·The Journal of Pain : Official Journal of the American Pain Society·Alvin J BeitzLaura Eikmeier
Mar 11, 2004·Journal of Clinical Nursing·Anke PersoonTheo van Achterberg
Jun 5, 2004·BMJ : British Medical Journal·Deborah A SimonCharles N McCollum
Jun 23, 2004·QJM : Monthly Journal of the Association of Physicians·C J MoffattF Ross
Sep 14, 2004·Advances in Skin & Wound Care·M Gail WoodburyDavid H Keast
Jul 21, 2006·BMC Medical Research Methodology·Judith M Watson, David J Torgerson
Jul 27, 2007·Health and Quality of Life Outcomes·Oliver R HerberMonika A Rieger
Oct 11, 2007·International Wound Journal·S Sauerland
Jan 24, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Matthew CardinalKeith Harding
Mar 21, 2008·Journal of Advanced Nursing·Satu Elo, Helvi Kyngäs
May 23, 2008·International Wound Journal·Patricia E PriceKeith G Harding
May 23, 2008·International Wound Journal·Kevin WooLuc Teot
Nov 28, 2008·BMC Health Services Research·Margaret B HarrisonTadeusz Pierscianowski
Jan 6, 2009·Critical Care Medicine·Donald M ArnoldUNKNOWN McMaster Critical Care Interest Group
Jan 8, 2010·BMC Medical Research Methodology·Lehana ThabaneCharles H Goldsmith
Mar 25, 2010·BMJ : British Medical Journal·Kenneth F SchulzUNKNOWN CONSORT Group
May 8, 2010·Dermatologic Clinics·Jacqueline E Denyer
May 27, 2010·Journal of Clinical Nursing·Raisa B Gul, Parveen A Ali
Jun 17, 2010·Journal of Wound Care·F GottrupUNKNOWN European Wound Management Association Patient Outcome Group
Nov 19, 2010·PLoS Medicine·Patrina H Y CaldwellJonathan C Craig
May 31, 2011·Journal of Pain and Symptom Management·Marianne Jensen HjermstadUNKNOWN European Palliative Care Research Collaborative (EPCRC)
Aug 23, 2011·Pain·Maria Alexandra Ferreira-ValenteMark P Jensen
Oct 16, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Carolina D WellerJohn J McNeil
Nov 1, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Karsten FoghBo Jørgensen
Nov 16, 2012·The Cochrane Database of Systematic Reviews·Michelle BriggsMarrissa Martyn-St James
Nov 28, 2012·BMC Medical Research Methodology·Janey C PetersonMary E Charlson
Feb 22, 2013·Statistical Methods in Medical Research·Melanie L Bell, Diane L Fairclough
Jul 16, 2013·SpringerPlus·Yiran Dong, Chao-Ying Joanne Peng
Nov 20, 2014·BMC Medical Research Methodology·Melanie L BellChiu-Hsieh Hsu
Jun 2, 2015·Advances in Wound Care·Roberto CuomoCesare Brandi
Jul 1, 2015·Journal of Empirical Research on Human Research Ethics : JERHRE·Jennifer H LinglerLauren A Terhorst

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

PASS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.