Evaluate the Malignancy of Pulmonary Nodules Using the 3-D Deep Leaky Noisy-OR Network

IEEE Transactions on Neural Networks and Learning Systems
Fangzhou LiaoSen Song

Abstract

Automatic diagnosing lung cancer from computed tomography scans involves two steps: detect all suspicious lesions (pulmonary nodules) and evaluate the whole-lung/pulmonary malignancy. Currently, there are many studies about the first step, but few about the second step. Since the existence of nodule does not definitely indicate cancer, and the morphology of nodule has a complicated relationship with cancer, the diagnosis of lung cancer demands careful investigations on every suspicious nodule and integration of information of all nodules. We propose a 3-D deep neural network to solve this problem. The model consists of two modules. The first one is a 3-D region proposal network for nodule detection, which outputs all suspicious nodules for a subject. The second one selects the top five nodules based on the detection confidence, evaluates their cancer probabilities, and combines them with a leaky noisy-OR gate to obtain the probability of lung cancer for the subject. The two modules share the same backbone network, a modified U-net. The overfitting caused by the shortage of the training data is alleviated by training the two modules alternately. The proposed model won the first place in the Data Science Bowl 2017 competition.

Citations

May 30, 2019·Physics in Medicine and Biology·Guobin ZhangLu Wang
Oct 11, 2019·Medical Physics·Umair JavaidJohn A Lee
Dec 10, 2019·Journal of X-ray Science and Technology·Yu WangLiqin Zhao
Aug 21, 2019·Journal of Clinical Medicine·Aryan MobinyHien Van Nguyen
Dec 17, 2019·Frontiers of Medicine·Jiechao MaJianlin Wu
Aug 25, 2020·National Academy Science Letters·N R RaajanNatarajan Prabaharan
Aug 25, 2020·Machine Vision and Applications·Hanan FarhatRima Kilany
Oct 11, 2020·Nature Communications·Cheng JinJianjiang Feng
Oct 17, 2020·Journal of Medical Imaging·Juezhao YuJiantao Pu
Nov 2, 2020·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Jia GuFangzheng Tian
Nov 11, 2020·Sustainable Cities and Society·Sweta BhattacharyaMd Jalil Piran
Oct 20, 2020·Medical Image Analysis·Xavier Rafael-PalouMiguel A González Ballester
Feb 4, 2021·Journal of Digital Imaging·Kushal MehtaDavid R Chapman
Jan 31, 2021·Nature Reviews. Cancer·Andreas KleppeHåvard E Danielsen
Mar 30, 2021·Journal of Healthcare Engineering·Eali Stephen Neal JoshuaYung-Cheol Byun
Mar 29, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Mehdi AstarakiChunliang Wang
Oct 22, 2020·Current Medical Imaging·Hafiz Mughees AhmadKhurram Khurshid
Apr 13, 2021·Multimedia Tools and Applications·Muralikrishna Puttagunta, S Ravi
Apr 22, 2021·Future Oncology·Ning LiJingmei Jiang
May 12, 2021·Pattern Recognition·Junlin HouXiangyang Xue
Nov 11, 2020·Diagnostic and Interventional Imaging·D BlancJ Brehant
Jul 1, 2021·European Journal of Hybrid Imaging·Martina SolliniPaola A Erba
Aug 31, 2021·Computers in Biology and Medicine·Yu GuXiaoqi Lu
Sep 4, 2021·Computer Methods and Programs in Biomedicine·Shaohua ZhengLiqin Huang
Nov 3, 2021·Interdisciplinary Sciences, Computational Life Sciences·Yifei XuChuanliang Chen
Oct 19, 2019·Academic Radiology·Vasantha Kumar VenugopalHarsh Mahajan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.