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Evaluating accuracy of microsatellite markers for classification of recurrent infections during routine monitoring of anti-malarial drug efficacy: A computer modelling approach

Antimicrobial Agents and Chemotherapy

Jan 15, 2020

Sam JonesIan Hastings

Abstract

Anti-malarial drugs have long half-lives, so clinical trials to monitor their efficacy require long durations of follow-up to capture drug failure that may only become patent weeks after treatment. Reinfections often occur during follow-up so robust methods of distinguishing drug failur...read more

Mentioned in this Paper

Pharmacologic Substance
Short Tandem Repeat
Test Method
Clinical Trials
In Vivo
Recurrence (Disease Attribute)
Follow-up
Disease Transmission
Study Site
Analysis
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Evaluating accuracy of microsatellite markers for classification of recurrent infections during routine monitoring of anti-malarial drug efficacy: A computer modelling approach

Antimicrobial Agents and Chemotherapy

Jan 15, 2020

Sam JonesIan Hastings

PMID: 31932376

DOI: 10.1128/aac.01517-19

Abstract

Anti-malarial drugs have long half-lives, so clinical trials to monitor their efficacy require long durations of follow-up to capture drug failure that may only become patent weeks after treatment. Reinfections often occur during follow-up so robust methods of distinguishing drug failur...read more

Mentioned in this Paper

Pharmacologic Substance
Short Tandem Repeat
Test Method
Clinical Trials
In Vivo
Recurrence (Disease Attribute)
Follow-up
Disease Transmission
Study Site
Analysis

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Malaria Vaccines

Research for development of a malaria vaccine is currently underway to find an effective modality to control and eliminate the transmission of malaria. To date, no vaccine has been found to be efficacious in fighting against malaria. Here is the latest research on malaria vaccines.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

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