Evaluating Adherence of Health-Care Team to Standard Guideline of Colistin Use at Intensive Care Units of a Referral Hospital in Shiraz, Southwest of Iran

Advanced Pharmaceutical Bulletin
Afsaneh VazinDena Firouzabadi

Abstract

Purpose: To evaluate colistin use according to global standard drug consumption in intensive care units of a referral hospital in Shiraz, Iran Methods: A prospective, interventional study was performed during an 11 month period on 100 patients admitted to ICUs of a teaching hospital being treated with colistin for at least 3 subsequent doses. Required demographic, clinical, and paraclinical data were gathered by a pharmacist. Fifteen indexes were considered to evaluate colistin use. A clinical pharmacist reviewed indication and dose of colistin at the time of prescribing this agent. Results: In our study population, pneumonia (69%) was the main indication of colistin. In 87% of patients, colistin administration was based on microbiological laboratory evidence. Continuation of therapy was inappropriate in 5% of cases. By the intervention of the clinical pharmacist, colistin was discontinued in all patients in whom empirical therapy was continued incorrectly. None of the patients received loading dose of colistin. The maintenance dose, dose interval, and duration of treatment of colistin were appropriate in 76%, 71%, and 100% of patients, respectively. For none of the patients, the pharmacokinetic dosing method was used. In all p...Continue Reading

Citations

Jan 24, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Afsaneh NoormandiHossein Khalili
Jun 26, 2020·Journal of Experimental Pharmacology·Afsaneh VazinZahra Khodami

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Methods Mentioned

BETA
pharmacotherapy

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Statistical Package for the Social Sciences ( SPSS )

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