Evaluating Alternative Materials for the Treatment of Stress Urinary Incontinence and Pelvic Organ Prolapse: A Comparison of the In Vivo Response to Meshes Implanted in Rabbits

The Journal of Urology
Sabiniano RomanSheila MacNeil

Abstract

Serious complications can develop with the mesh implants used for stress urinary incontinence and pelvic organ prolapse surgery. We evaluated 2 materials currently in clinical use and 2 alternative materials using a rabbit abdominal model to assess host response and biomechanical properties of the materials before and after implantation. Poly-L-lactic acid and polyurethane meshes were electrospun to be compared to commercially available polypropylene and polyvinylidene fluoride meshes. A total of 40 immunocompetent full-thickness abdominal wall defect rabbit models were used, including 8 in each of the poly-L-lactic acid, polyurethane, polyvinylidene fluoride and polypropylene experimental groups, and sham controls. Two 20 mm defects were created per animal and primarily repaired. The experimental groups then underwent onlay of each repair material while sham controls did not. Four rabbits per group were sacrificed at days 30 and 90. Abdominal wall specimens containing the defect with or without repair material were explanted to be assessed by histology (hematoxylin and eosin staining, and immunohistochemistry) and biomechanical testing at 30 and 90 days. At 90 days of implantation tissues repaired with all 4 materials showed b...Continue Reading

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Citations

Jan 24, 2018·Nature Reviews. Urology·Sheila MacNeilMargot Damaser
Aug 12, 2017·Neurourology and Urodynamics·Mahshid VashaghianJan-Paul Roovers
Mar 2, 2016·Nature Reviews. Urology·Peter Sidaway
Jun 21, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Elena MancusoPeter Culmer
Apr 23, 2019·Current Opinion in Urology·Katerina MackovaJan Deprest
Jun 25, 2019·F1000Research·Emma MironskaSheila MacNeil
Apr 1, 2019·Current Urology Reports·Joshua A Cohn, Ariana L Smith
Sep 25, 2019·Nature Reviews. Urology·Naşide MangirSheila MacNeil
Jun 11, 2020·Nanomaterials·Kallyanashis PaulShayanti Mukherjee
Oct 10, 2020·Actas urologicas españolas·J V Baldissera AradasR Ferrero Doria
Mar 7, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·E MacCraithN F Davis
Jul 3, 2017·Journal of the Mechanical Behavior of Biomedical Materials·Lucie HympanovaJan Deprest
Jul 28, 2021·Journal of Biomaterials Science. Polymer Edition·Deyu YangKehai Liu
Dec 6, 2021·BJOG : an International Journal of Obstetrics and Gynaecology·Chantal M DiedrichJan Paul Roovers

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