Evaluating Alzheimer's Disease Progression by Modeling Crosstalk Network Disruption

Frontiers in Neuroscience
Haochen LiuXiaoquan Liu

Abstract

Aβ, tau, and P-tau have been widely accepted as reliable markers for Alzheimer's disease (AD). The crosstalk between these markers forms a complex network. AD may induce the integral variation and disruption of the network. The aim of this study was to develop a novel mathematic model based on a simplified crosstalk network to evaluate the disease progression of AD. The integral variation of the network is measured by three integral disruption parameters. The robustness of network is evaluated by network disruption probability. Presented results show that network disruption probability has a good linear relationship with Mini Mental State Examination (MMSE). The proposed model combined with Support vector machine (SVM) achieves a relative high 10-fold cross-validated performance in classification of AD vs. normal and mild cognitive impairment (MCI) vs. normal (95% accuracy, 95% sensitivity, 95% specificity for AD vs. normal; 90% accuracy, 94% sensitivity, 83% specificity for MCI vs. normal). This research evaluates the progression of AD and facilitates AD early diagnosis.

References

Sep 25, 2003·Lancet Neurology·Kaj Blennow, Harald Hampel
Jun 3, 2004·Neurobiology of Aging·Edward ZamriniMartin Tolar
Jun 14, 2006·Archives of Neurology·Matthew R PowellRobert J Ivnik
Oct 24, 2006·Trends in Molecular Medicine·Yong ShenKristina Lindholm
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sergei Maslov, I Ispolatov
Aug 5, 2008·Trends in Neurosciences·Ilya Bezprozvanny, Mark P Mattson
Feb 18, 2009·Journal of Alzheimer's Disease : JAD·Miroslaw BrysMony J de Leon
Mar 20, 2009·Annals of Neurology·Leslie M ShawUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Feb 9, 2010·Journal of Proteome Research·Jing ZhaoZhiwei Cao
Nov 9, 2010·Progress in Neurobiology·Antero SalminenHilkka Soininen
Dec 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Allal BoutajangoutEinar M Sigurdsson
Dec 17, 2010·Neurobiology of Aging·Michael EwersUNKNOWN North American Alzheimer's Disease Neuroimaging Initiative (ADNI)
Dec 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karl Herrup
May 31, 2011·Neurobiology of Aging·María-Ximena SilveyraJavier Sáez-Valero
Sep 29, 2011·Frontiers in Molecular Neuroscience·María-Salud García-AyllónJavier Sáez-Valero
Oct 14, 2011·NeuroImage·Daoqiang ZhangUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Nov 8, 2011·Journal of Molecular Neuroscience : MN·Hanna Rosenmann
Dec 17, 2011·NeuroImage·Eric M Reiman, William J Jagust
Apr 25, 2012·Archives of Neurology·Rahul S DesikanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Apr 16, 2013·NeuroImage·Jiayu ZhouUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Nov 2, 2013·Brain : a Journal of Neurology·Yen Ying LimUNKNOWN AIBL Research Group
Nov 20, 2013·PloS One·Ramon CasanovaUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 24, 2014·The New England Journal of Medicine·Rachelle S DoodyUNKNOWN Solanezumab Study Group
Mar 7, 2014·Journal of Alzheimer's Disease : JAD·Diane P HangerWendy Noble
Mar 19, 2014·NeuroImage. Clinical·Liana G ApostolovaUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 15, 2014·Integrative and Comparative Biology·H Frederik Nijhout, Michael C Reed
Jul 22, 2014·NeuroImage·Heung-Il SukUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 22, 2014·Cell Biology International·Ahmed M SalemHadeer A Aglan
Aug 1, 2014·Frontiers in Molecular Neuroscience·Taeko KimuraShin-Ichi Hisanaga
Aug 1, 2014·Journal of Alzheimer's Disease : JAD·Paula Grammas, Joseph M Martinez
Sep 3, 2014·BMC Neurology·Michael A CastelloSalvador Soriano
Sep 22, 2015·Frontiers in Neuroscience·Christian SalvatoreUNKNOWN Alzheimer's Disease Neuroimaging Initiative

❮ Previous
Next ❯

Citations

Jun 9, 2016·Scientific Reports·Haochen LiuUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Early Markers

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive and behavioral decline. Targeting markers in the earliest stages of the disease may mitigate the progression of AD. This feed focuses on early diagnosis and markers, as well as environmental, pharmacological, and drug-response biomarkers associated with this disease.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Related Papers

The Director : Official Publication of the National Association of Directors of Nursing Administration in Long Term Care
L Kurlowicz, M Wallace
Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Annapaola PrestiaAlzheimer's Disease Neuroimaging Initiative
Clinical Laboratory
Valentina De RivaFrancesco Perini
© 2021 Meta ULC. All rights reserved