Evaluating Antiplasmodial and Antimalarial Activities of Soybean (Glycine max ) Seed Extracts on P. falciparum Parasite Cultures and P. berghei -Infected Mice

Journal of Pathogens
Kevin NyandwaroAmos Mbugua

Abstract

Plasmodium parasite resistance to artemisinin-based combination therapies (ACTs) calls for development of new, affordable, safe, and effective antimalarial drugs. Studies conducted previously on soybean extracts have established that they possess antimicrobial, anti-inflammatory, anticancerous, and antioxidant properties. The activity of such extracts on Plasmodium parasite resistance to artemisinin-based combination therapies (ACTs) calls for development of new, affordable, safe, and effective antimalarial drugs. Studies conducted previously on soybean extracts have established that they possess antimicrobial, anti-inflammatory, anticancerous, and antioxidant properties. The activity of such extracts on. The aim of this study was to determine the antiplasmodial activity of soybean extracts using Plasmodium falciparum cultures, followed by an in vivo evaluation of safety and antimalarial activity of the extracts in Plasmodium berghei ANKA strain-infected mice. Aqueous, methanol, and peptide extracts of soybean seeds were prepared. An in vitro evaluation of the extracts for antiplasmodial activity was carried out using two P. falciparum strains: D6, a chloroquine-sensitive Sierra Leone 1 strain and W2, a chloroquine-resistant In...Continue Reading

References

Dec 1, 1979·Antimicrobial Agents and Chemotherapy·R E DesjardinsJ D Chulay
Aug 20, 1976·Science·W Trager, J B Jensen
Jun 1, 1970·Annals of Tropical Medicine and Parasitology·J F Ryley, W Peters
Sep 1, 1984·The American Journal of Tropical Medicine and Hygiene·D G SixsmithH C Spencer
Dec 1, 1983·Archives of Toxicology·D Lorke
Dec 1, 1995·International Journal for Parasitology·E DeharoH Ginsburg
Oct 31, 2000·Phytotherapy Research : PTR·M Heinrich
Sep 14, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Djordje MalencićJegor Miladinović
Aug 25, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ronan BatistaAlaíde Braga de Oliveira
Jan 11, 2011·Indian Journal of Pharmaceutical Sciences·P GhoshA Saha
Jun 10, 2011·Journal of Natural Products·A Douglas KinghornHeebyung Chai
Aug 29, 2013·Journal of Tropical Medicine·Mikhail Olugbemiro NafiuMusbau Adewumi Akanji
Dec 20, 2013·Nature·Frédéric ArieyDidier Ménard
Dec 24, 2014·Critical Reviews in Clinical Laboratory Sciences·Gian Luca SalvagnoGiuseppe Lippi
Jun 19, 2015·Nature·Beatriz BaragañaIan H Gilbert
Sep 25, 2015·Emerging Infectious Diseases·Sandie MénardFrançoise Benoit-Vical
Feb 12, 2017·Pharmaceutical Biology·Jude E OkokonDinesh Mohanakrishnan
Nov 21, 2017·Lancet·Donald A P BundyUNKNOWN Disease Control Priorities-3 Child and Adolescent Health and Development Authors Group
May 29, 2018·Drugs·Elizabeth A Ashley, Aung Pyae Phyo
Jul 7, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Léa Nadège BonkianMaminata Traore/Coulibaly

❮ Previous
Next ❯

Citations

Aug 29, 2020·Journal of Tropical Medicine·Tekleab TekaHaile Kassahun

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy

Software Mentioned

MS Excel
SPSS
Excel

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.