Abstract
Plasmodium parasite resistance to artemisinin-based combination therapies (ACTs) calls for development of new, affordable, safe, and effective antimalarial drugs. Studies conducted previously on soybean extracts have established that they possess antimicrobial, anti-inflammatory, anticancerous, and antioxidant properties. The activity of such extracts on Plasmodium parasite resistance to artemisinin-based combination therapies (ACTs) calls for development of new, affordable, safe, and effective antimalarial drugs. Studies conducted previously on soybean extracts have established that they possess antimicrobial, anti-inflammatory, anticancerous, and antioxidant properties. The activity of such extracts on. The aim of this study was to determine the antiplasmodial activity of soybean extracts using Plasmodium falciparum cultures, followed by an in vivo evaluation of safety and antimalarial activity of the extracts in Plasmodium berghei ANKA strain-infected mice. Aqueous, methanol, and peptide extracts of soybean seeds were prepared. An in vitro evaluation of the extracts for antiplasmodial activity was carried out using two P. falciparum strains: D6, a chloroquine-sensitive Sierra Leone 1 strain and W2, a chloroquine-resistant In...Continue Reading
References
Dec 1, 1979·Antimicrobial Agents and Chemotherapy·R E DesjardinsJ D Chulay
Aug 20, 1976·Science·W Trager, J B Jensen
Jun 1, 1970·Annals of Tropical Medicine and Parasitology·J F Ryley, W Peters
Aug 1, 1965·Experimental Parasitology·W Peters
Sep 1, 1984·The American Journal of Tropical Medicine and Hygiene·D G SixsmithH C Spencer
Dec 1, 1983·Archives of Toxicology·D Lorke
Dec 1, 1995·International Journal for Parasitology·E DeharoH Ginsburg
Jul 22, 1999·Biochemistry·D MontiD Taramelli
Feb 29, 2000·British Journal of Pharmacology·E NúñezC Aragón
Oct 31, 2000·Phytotherapy Research : PTR·M Heinrich
Nov 25, 2000·Journal of Ethnopharmacology·M S MuellerE Wemakor
Feb 8, 2002·Nature·Robert G Ridley
Sep 14, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Djordje MalencićJegor Miladinović
Dec 11, 2007·Journal of Ethnopharmacology·J W GathirwaI O Ndiege
Jun 20, 2008·Biotechnology and Applied Biochemistry·Ling ZhangKexuan Tang
Aug 25, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ronan BatistaAlaíde Braga de Oliveira
Jan 11, 2011·Indian Journal of Pharmaceutical Sciences·P GhoshA Saha
Mar 18, 2011·Malaria Journal·Hagai Ginsburg, Eric Deharo
Jun 10, 2011·Journal of Natural Products·A Douglas KinghornHeebyung Chai
Aug 29, 2013·Journal of Tropical Medicine·Mikhail Olugbemiro NafiuMusbau Adewumi Akanji
Dec 20, 2013·Nature·Frédéric ArieyDidier Ménard
Nov 26, 2014·Malaria Journal·Protus Arrey TarkangAnastasia N Guantai
Dec 24, 2014·Critical Reviews in Clinical Laboratory Sciences·Gian Luca SalvagnoGiuseppe Lippi
Jun 19, 2015·Nature·Beatriz BaragañaIan H Gilbert
Sep 25, 2015·Emerging Infectious Diseases·Sandie MénardFrançoise Benoit-Vical
Feb 12, 2017·Pharmaceutical Biology·Jude E OkokonDinesh Mohanakrishnan
Jul 6, 2017·Malaria Journal·Judith RechtMarcus V G Lacerda
Aug 5, 2017·Nature Medicine·Benjamin BlascoDavid A Fidock
Nov 21, 2017·Lancet·Donald A P BundyUNKNOWN Disease Control Priorities-3 Child and Adolescent Health and Development Authors Group
May 29, 2018·Drugs·Elizabeth A Ashley, Aung Pyae Phyo
Jul 7, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Léa Nadège BonkianMaminata Traore/Coulibaly