Abstract
In May 2008, the Food and Drug Administration launched the Sentinel Initiative, a multi-year program for the establishment of a national electronic monitoring system for medical product safety that led, in 2016, to the launch of the full Sentinel System. Under the Mini-Sentinel pilot, several algorithms for identifying health outcomes of interest, including one for anaphylaxis, were developed and evaluated using data available from the Sentinel common data model. To evaluate whether features extracted from unstructured narrative data using natural language processing (NLP) could be used to classify anaphylaxis cases. Using previously developed methods, we extracted features from unstructured narrative data using NLP and applied rule-based and similarity-based algorithms to identify anaphylaxis among 62 potential cases previously classified by human experts as anaphylaxis (N = 33), not anaphylaxis (N = 27), and unknown (N = 2). The rule-based and similarity-based approaches demonstrated almost equal performance (recall 100% vs 100%, precision 60.3% vs 57.4%, F-measure: 0.753 vs 0.729). Reasons for misclassification included the inability of the algorithms to make the same clinical judgments as human experts about the timing, sev...Continue Reading
References
Mar 21, 2006·Annals of Emergency Medicine·Hugh A SampsonWyatt W Decker
Apr 24, 2007·Vaccine·Jens U RüggebergUNKNOWN Brighton Collaboration Anaphylaxis Working Group
May 20, 2008·Journal of Biomedical Informatics·Hui CaoGeorge Hripcsak
May 6, 2010·Journal of the American Medical Informatics Association : JAMIA·Alan R Aronson, François-Michel Lang
Jan 14, 2011·The New England Journal of Medicine·Rachel E BehrmanRichard Platt
Jun 29, 2011·Journal of the American Medical Informatics Association : JAMIA·Taxiarchis BotsisRobert Ball
Jan 25, 2012·Pharmacoepidemiology and Drug Safety·Ryan M Carnahan, Kevin G Moores
Aug 28, 2012·Journal of the American Medical Informatics Association : JAMIA·Taxiarchis BotsisRobert Ball
May 8, 2013·Applied Clinical Informatics·T BotsisR Ball
May 25, 2013·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Taxiarchis BotsisRobert Ball
Sep 17, 2013·Pharmacoepidemiology and Drug Safety·Kathleen E WalshSusan Andrade
Aug 19, 2015·Pharmacoepidemiology and Drug Safety·Stephan LanesAlexander M Walker
Dec 17, 2015·Clinical Pharmacology and Therapeutics·R BallG Dal Pan
Jan 5, 2016·International Journal of Medical Informatics·Alexander M WalkerRobert F Reynolds
Feb 26, 2016·Journal of the American Medical Informatics Association : JAMIA·Elizabeth FordJackie A Cassell
Aug 2, 2016·Journal of Biomedical Informatics·Taxiarchis BotsisJohn Scott
Citations
Mar 17, 2019·American Journal of Epidemiology·Susan M ShortreedJennifer C Nelson
Dec 5, 2019·Pharmacoepidemiology and Drug Safety·Wei YuSteven J Jacobsen
Apr 13, 2020·Journal of the American Medical Informatics Association : JAMIA·Jeffrey S BrownRobert Ball
Aug 28, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Shirley V WangAndrew Bate
Jun 28, 2019·The Journal of Allergy and Clinical Immunology·Rachel L MillerAleena Banerji
Apr 27, 2021·Pharmacoepidemiology and Drug Safety·Daniel C BeachlerChuntao Wu
Aug 22, 2021·Pharmacoepidemiology and Drug Safety·Dominik de SordiAntje Timmer
Nov 17, 2021·Experimental Biology and Medicine·Elke AnklamWilliam Slikker