Evaluating autonomy, beneficence, and justice with substance-using populations: Implications for clinical research participation

Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors
Justin C Strickland, William W Stoops

Abstract

Narrow inclusion criteria regarding substance use are commonplace in clinical research. This is due, in part, to assumptions about capacity to make "rational" decisions regarding participation by these populations. This study evaluated decision-making and perceptions surrounding each of the Belmont principles among individuals with cocaine use histories, cigarette smokers without illicit substance use histories, and controls without cigarette or illicit substance use histories. Cocaine (n = 124), cigarette (n = 128), and control (n = 145) groups were recruited using Amazon's Mechanical Turk. Participants completed measures evaluating research participation after reading two hypothetical study vignettes varying in risk. Assays assessed capacity to consent, perceived research burden, and endorsement of research participation by various populations. Individuals reporting cocaine use showed a reduced capacity to consent compared to controls, but this effect was small and largely explained by sociodemographic differences (e.g., race) rather than substance use history. Perceived research burden in the cigarette group was lower than in the cocaine group, but this difference was of a small to medium effect size. All groups reported sub...Continue Reading

Citations

Aug 20, 2020·The American Journal of Drug and Alcohol Abuse·Justin C StricklandWilliam W Stoops
Feb 23, 2019·Journal of Psychopharmacology·Justin C StricklandWilliam W Stoops
Apr 29, 2019·Drug and Alcohol Dependence·Justin C StricklandWilliam W Stoops
Aug 3, 2021·Drug and Alcohol Dependence·Erin FergusonJeff Boissoneault

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