Abstract
To evaluate the thrombus maturity noninvasively providing the promise of much earlier and more accurate diagnosis of diseases ranging from stroke to myocardial infarction to deep vein thrombosis. Magnetic spectroscopy of nanoparticle Brownian rotation (MSB), a form of magnetic particle spectroscopy sensitive to Brownian rotation of magnetic nanoparticles, was used for the detection and characterization of blood clots. The nanoparticles' relaxation time was quantified by scaling the MSB spectra in frequency to match the spectra from nanoparticles in a reference state. The nanoparticles' relaxation time, in the bound state, was used to characterize the nanoparticle binding to thrombin on the blood clot. The number of nanoparticles bound to the clot was also estimated. Both the relaxation time and the weight of bound nanoparticles were obtained for clots of several ages, reflecting different stages of development and organization. The impact of clot development was explored using functionalized nanoparticles present during clot formation. The relaxation time of the bound nanoparticles decreases for more mature, organized clots. The number of nanoparticles able to bind the clot diminishes quantitatively with clot age. On mature clo...Continue Reading
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Citations
Apr 21, 2020·Physics in Medicine and Biology·John B WeaverSteven N Fiering
Mar 16, 2021·ACS Omega·Kai WuJian-Ping Wang
Mar 10, 2020·ACS Applied Materials & Interfaces·Kai WuJian-Ping Wang
Jun 2, 2020·ACS Omega·Kai WuJian-Ping Wang
Sep 10, 2021·ACS Applied Materials & Interfaces·Kai WuJian-Ping Wang