Evaluating changes in tendon crimp with fatigue loading as an ex vivo structural assessment of tendon damage

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Benjamin R FreedmanLouis J Soslowsky

Abstract

The complex structure of tendons relates to their mechanical properties. Previous research has associated the waviness of collagen fibers (crimp) during quasi-static tensile loading to tensile mechanical properties, but less is known about the role of fatigue loading on crimp properties. In this study (IACUC approved), mouse patellar tendons were fatigue loaded while an integrated plane polariscope simultaneously assessed crimp properties. We demonstrate a novel structural mechanism whereby tendon crimp amplitude and frequency are altered with fatigue loading. In particular, fatigue loading increased the crimp amplitude across the tendon width and length, and these structural alterations were shown to be both region and load dependent. The change in crimp amplitude was strongly correlated to mechanical tissue laxity (defined as the ratio of displacement and gauge length relative to the first cycle of fatigue loading assessed at constant load throughout testing), at all loads and regions evaluated. Together, this study highlights the role of fatigue loading on tendon crimp properties as a function of load applied and region evaluated, and offers an additional structural mechanism for mechanical alterations that may lead to ultim...Continue Reading

References

Mar 14, 1972·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J DiamantR G Arridge
May 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J A Hannafin, S P Arnoczky
Aug 1, 1997·Journal of Biomechanics·H Schechtman, D L Bader
Nov 24, 1999·The Journal of Physiology·C N Maganaris, J P Paul
Dec 18, 2001·Journal of Applied Physiology·Paolo P ProvenzanoRay Vanderby
Mar 2, 2002·Journal of Biomechanical Engineering·Kristi A HansenJennifer K Barton
Jun 12, 2003·Annals of Biomedical Engineering·Tishya A L WrenDennis R Carter
Aug 1, 1965·Biological Reviews of the Cambridge Philosophical Society·D H ELLIOTT
Jul 19, 2005·Journal of Biomechanics·Stavros ThomopoulosGuy M Genin
Nov 8, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·Paolo P Provenzano, Ray Vanderby
Jan 19, 2007·Journal of Anatomy·Marco FranchiAlessandro Ruggeri
Aug 8, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·David T FungEvan L Flatow
Dec 17, 2008·Journal of Applied Physiology·Trevor J LujanJeffrey A Weiss
Nov 1, 1959·The Journal of General Physiology·B J RigbyH Eyring
Nov 27, 2009·Journal of Biomechanics·David T FungEvan L Flatow
Jan 9, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Cathryn D PeltzLouis J Soslowsky
Apr 20, 2010·Journal of Biomechanics·Armin EilaghiC Ross Ethier
Jul 16, 2010·Journal of Biomechanics·Jedd B SereyskyEvan L Flatow
Feb 3, 2011·Annals of Biomedical Engineering·Gabriel ParentEve Langelier
Nov 11, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jedd B SereyskyEvan L Flatow
Jan 10, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nelly Andarawis-PuriEvan L Flatow
Mar 9, 2012·Annals of Biomedical Engineering·Sarah Duenwald-KuehlRay Vanderby
Oct 26, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Benjamin R Freedman, Frances T Sheehan
Nov 28, 2012·Matrix Biology : Journal of the International Society for Matrix Biology·Andrew A DunkmanLouis J Soslowsky
Dec 21, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Samuel P VeresJ Michael Lee
Jul 11, 2013·International Journal of Experimental Pathology·Jennifer H Shepherd, Hazel R C Screen
Nov 28, 2013·Journal of Biomechanics·Benjamin R FreedmanLouis J Soslowsky
Nov 29, 2013·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Jennifer H ShepherdHazel R C Screen
Dec 21, 2013·Journal of Biomechanical Engineering·Corinne N RigginLouis J Soslowsky
Jan 10, 2014·Journal of the Royal Society, Interface·Chavaunne T ThorpeHazel R C Screen
Aug 22, 2014·The American Journal of Sports Medicine·Alice J S FoxScott A Rodeo

❮ Previous
Next ❯

Citations

May 2, 2015·Biochimica Et Biophysica Acta·Benjamin R FreedmanPaul A Janmey
Apr 3, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Benjamin R FreedmanLouis J Soslowsky
Nov 24, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michael LavagninoSteven P Arnoczky
Mar 26, 2019·Advanced Materials·Benjamin R Freedman, David J Mooney
Feb 6, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Cody D HillinLouis J Soslowsky
May 7, 2016·Annals of Biomedical Engineering·A M PardesL J Soslowsky
Feb 23, 2018·Journal of the Royal Society, Interface·Benjamin R FreedmanLouis J Soslowsky
Jul 10, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Andrey ZuskovLouis J Soslowsky
Aug 25, 2017·The Journal of the American Academy of Orthopaedic Surgeons·Benjamin R FreedmanLouis Soslowsky
Nov 3, 2016·Journal of Applied Physiology·George W FryhoferLouis J Soslowsky
Oct 27, 2017·Annals of the New York Academy of Sciences·Andrea H Lee, Dawn M Elliott
Jul 20, 2018·Scientific Reports·Benjamin R FreedmanLouis J Soslowsky
Apr 13, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Andrea H Lee, Dawn M Elliott
Nov 18, 2017·ACS Biomaterials Science & Engineering·Spencer E SzczesnyPen-Hsiu G Chao
Jul 30, 2021·Acta Biomaterialia·Patrick M WilliamsonAra Nazarian
Oct 12, 2021·Microscopy Research and Technique·Anas K Al MakhzoomiGarry T Allison

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Nathan R SchieleCatherine K Kuo
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Jedd B SereyskyE L Flatow
© 2021 Meta ULC. All rights reserved