Evaluating clinician acceptability of the prototype CanRisk tool for predicting risk of breast and ovarian cancer: A multi-methods study

PloS One
Stephanie ArcherFiona M Walter

Abstract

There is a growing focus on the development of multi-factorial cancer risk prediction algorithms alongside tools that operationalise them for clinical use. BOADICEA is a breast and ovarian cancer risk prediction model incorporating genetic and other risk factors. A new user-friendly Web-based tool (CanRisk.org) has been developed to apply BOADICEA. This study aimed to explore the acceptability of the prototype CanRisk tool among two healthcare professional groups to inform further development, evaluation and implementation. A multi-methods approach was used. Clinicians from primary care and specialist genetics clinics in England, France and Germany were invited to use the CanRisk prototype with two test cases (either face-to-face with a simulated patient or via a written vignette). Their views about the tool were examined via a semi-structured interview or equivalent open-ended questionnaire. Qualitative data were subjected to thematic analysis and organised around Sekhon's Theoretical Framework of Acceptability. Seventy-five clinicians participated, 21 from primary care and 54 from specialist genetics clinics. Participants were from England (n = 37), France (n = 23) and Germany (n = 15). The prototype CanRisk tool was generall...Continue Reading

References

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Citations

Oct 21, 2020·Genes, Chromosomes & Cancer·Steffen HirschChristian P Schaaf
Feb 6, 2021·Diagnosis·Alice S ForsterGeorgios Lyratzopoulos
Dec 19, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Tim CarverAntonis C Antoniou
May 13, 2021·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Marc TischkowitzUNKNOWN ACMG Professional Practice and Guidelines Committee
Sep 1, 2021·The Breast : Official Journal of the European Society of Mastology·D Gareth EvansAnthony Howell
Aug 30, 2021·The Breast : Official Journal of the European Society of Mastology·Anne BrédartSylvie Dolbeault

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Methods Mentioned

BETA
contraception
Hormone Replacement Therapy

Software Mentioned

Qualtrics
BOADICEA
NVivo
CanRisk Tool
CanRisk
SystmOne

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