Evaluating diffusion-weighted magnetic resonance imaging for target volume delineation in head and neck radiotherapy

Journal of Medical Imaging and Radiation Oncology
Michael CardosoDion Forstner

Abstract

Inter-observer variability (IOV) in target volume delineation is a source of error in head and neck radiotherapy. Diffusion-weighted imaging (DWI) has been shown to be useful in detecting recurrent head and neck cancer. This study aims to determine whether DWI improves target volume delineation and IOV. Four radiation oncologists delineated the gross tumour volume (GTV) for ten head and neck cancer patients. Delineation was performed on CT alone as well as fused image sets which incorporated fluorodeoxyglucose (FDG)-positron emission tomography (PET) and magnetic resonance imaging (MRI) in the form of CT/PET, CT/PET/T2W and CT/PET/T2W/DWI image sets. Analysis of the variability of contour volumes was completed by comparison to the simultaneous truth and performance level estimation (STAPLE) volumes. The DICE Similarity Coefficient (DSC) and other IOV metrics for each observer's contour were compared to the STAPLE for each patient and image dataset. A DWI usability scoresheet for delineation was completed. The CT/PET/T2W/DWI mean GTV volume of 13.37 (10.35-16.39)cm3 was shown to be different to the mean GTV of 10.92 (8.32-13.51)cm3 when using CT alone (P < 0.001). The GTV DSC amongst observers for CT alone was 0.72 (0.65-0.79), ...Continue Reading

References

Jan 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·V S KhooM O Leach
May 30, 2003·Medical Physics·Joseph O DeasyVanessa H Clark
May 28, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Xavier GeetsVincent Grégoire
Mar 5, 2010·IEEE Transactions on Medical Imaging·Olivier Commowick, Simon K Warfield
Oct 21, 2010·Journal of Medical Imaging and Radiation Oncology·Michael G JamesonPeter E Metcalfe
Feb 16, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Vincent Grégoire, Arturo Chiti
Jan 28, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·I FotinaD Georg
Feb 12, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Antonetta C HouwelingUulke A van der Heide
Apr 27, 2013·Technology in Cancer Research & Treatment·P MetcalfeW Tome
Apr 24, 2014·International Journal of Radiation Oncology, Biology, Physics·Entesar DalahX Allen Li
Jan 24, 2015·Radiation Oncology·Elise Anne JagerCornelis P J Raaijmakers
Dec 25, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Johannes Peter Maarten BurbachMartijn Intven
Oct 13, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Shalini K VinodLois C Holloway
Mar 6, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hans LigtenbergMarielle E P Philippens

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Citations

Feb 23, 2021·Frontiers in Oncology·Pierre DecazesPierre Vera
Nov 2, 2019·Hematology/oncology Clinics of North America·Sonja StiebClifton David Fuller
Jul 14, 2021·Journal of Digital Imaging·Vanessa De Araujo FariaLuiz Otavio Murta Junior

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