Evaluating diurnal variations in retinal perfusion using optical coherence tomography angiography

International Journal of Retina and Vitreous
Felix RommelMahdy Ranjbar

Abstract

Optical coherence tomography angiography (OCTA) is a non-invasive tool for imaging and quantifying the retinal and choroidal vasculature as well as perfusion state in healthy eyes. Choroidal perfusion is subject to diurnal variation, showing lowest perfusion in the morning and highest in the afternoon. In this index study, OCTA was used to investigate diurnal changes of the retinal perfusion in healthy adult eyes and to identify impacting factors since retinal perfusion is known to be mainly determined by autoregulatory mechanisms. A prospective study was conducted on healthy volunteers, each of whom underwent repeated measurements of mean arterial pressure (MAP), intraocular pressure (IOP), macular volume (MV), subfoveal choroidal thickness (SFCT), foveal avascular zone (FAZ) and retinal perfusion of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and full retina (FR) slab at 7 a.m. and 4 p.m. Possible influence of MAP or IOP on the retinal perfusion was evaluated. A total of 22 eyes of 22 participants (mean age 55.91 ± 14.84) were analysed. Significant diurnal changes from 7 a.m. to 4 p.m. were observed for MAP (p < 0.001) and SFCT (p = 0.017). The perfusion of SCP, DCP and FR as well as the size of the FA...Continue Reading

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Citations

Feb 27, 2021·Scientific Reports·Keiko AzumaRyo Obata
Jun 27, 2021·Journal of Glaucoma·Jo-Hsuan WuRobert N Weinreb
Dec 11, 2021·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Dan SamahaAriane Dupont

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Software Mentioned

ImageJ
Prism GraphPad
SD
OCTA
SPSS
OCT

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