Evaluating Drug-Induced Liver Injury and Its Remission via Discrimination and Imaging of HClO and H2 S with a Two-Photon Fluorescent Probe

Analytical Chemistry
Xiaoyun JiaoBo Tang

Abstract

Drug-induced liver injury (DILI) has aroused wide concern. Finding new markers or indicators as well as detoxification molecules for DILI is of great significance and good application prospect, which can help develop effective preclinical screening methodology and corresponding treatment protocols. Herein, in this article, DILI caused by antidepressant drugs of duloxetine and fluoxetine and its remission were evaluated by a two-photon fluorescent probe, RPC-1, through discriminating and imaging HClO and H2S simultaneously. By being applied both in vitro and in vivo, RPC-1 revealed slight up-regulation of HClO and negligible liver damage after administration of either of the two drugs. In contrast, an apparent up-regulation of HClO and obvious liver damage was observed after combined administration of the drugs. Meanwhile, the pretreatment of N-acetyl cysteine (NAC) resulted in the increasing of endogenous H2S level, which contributed to the remission of DILI. The histological analysis and serological test both gave good consistency with the imaging results. These findings demonstrate that HClO may be an appropriate indicator of DILI, and H2S plays an important role in the antidotal effect of NAC. We envision that RPC-1 can be u...Continue Reading

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Citations

Jun 18, 2019·Chemical Society Reviews·Yongkang YueCaixia Yin
Jul 30, 2019·Chemical Communications : Chem Comm·Huawei NiuYufen Zhao
Feb 8, 2020·Chemical Communications : Chem Comm·Xiuxiu YueXiangzhi Song
Nov 7, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiuli ZhongJian Shen
Nov 23, 2019·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Wenqiang ChenLei Yang
Jan 1, 2021·Accounts of Chemical Research·Dan ChengXiao-Bing Zhang
Aug 30, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Yahui SunLiangliang Zhao
Jan 4, 2022·Analytical and Bioanalytical Chemistry·Jing Li, Xiaojiang Xie

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