Evaluating extent of resection in pediatric glioblastoma: a multiple propensity score-adjusted population-based analysis

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Hadie AdamsAlfredo Quiñones-Hinojosa

Abstract

The benefit of radical resections for glioblastoma patients remains a source of contention in the literature. Few studies have been conducted in pediatric patients, and it is becoming increasingly evident that data regarding adult glioblastoma (GB) patients cannot be generalized to pediatric patients affected by this neoplasm. A comparative effectiveness study is performed for different extent of resection (EOR) groups in the largest cohort of pediatric GB (pGB) patients. The Surveillance, Epidemiology, and End Results (SEER) cancer registry was used to identify pGB patients from 1988 through 2009. Multivariate- and multiple propensity score (mPS)-adjusted analyses were used to determine the effect of gross total resection (GTR), partial resection (PR), and biopsy (Bx) on overall survival. Survival prospects were summarized using direct adjusted survival curves. A total of 342 pGB patients were identified, and 35.4 % of patients received a GTR, 28.8 % PR, 17.3 % Bx, and 17.0 % did not undergo surgery. In our cohort, a median overall survival of 12 months was observed with 1-, 2-, and 5-year survival rates of 51.7, 28.3, and 15.7 %, respectively. EOR was a predictor of survival in both the multivariate- (P < 0.001) and mPS-adjus...Continue Reading

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Citations

Nov 5, 2016·Journal of Neurosurgery. Pediatrics·Subhas K KonarAnil Nanda
Apr 22, 2017·World Neurosurgery·Daniel M TrifilettiTimothy N Showalter
May 26, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Rami Walid ChakrounHonggang Cui
Mar 14, 2018·Cancer Medicine·Meng LiuJohn L Villano
Jun 4, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Alok Mohan UpparVani Santosh
Nov 2, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·F LakhdarF M Chaoui
Sep 9, 2020·Journal of Neuro-oncology·Henry Ruiz-GarciaDaniel M Trifiletti
Apr 21, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Subhash GuptaGoura Kishor Rath
Jan 29, 2020·Cancer Metastasis Reviews·Christina ColemanSabine Mueller
Jul 10, 2020·Neuro-oncology Advances·Sindhoosha MalayJill S Barnholtz-Sloan
Apr 2, 2021·Radiation Oncology Journal·Aditya Kumar SinglaChirag K Ahuja
May 1, 2021·Cancers·Aleksandra NapieralskaMaciej Harat

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