Evaluating feasibility and accuracy of non-invasive tests for nonalcoholic fatty liver disease in severe and morbid obesity

International Journal of Obesity : Journal of the International Association for the Study of Obesity
G J OoiWendy A Brown

Abstract

In obese individuals, nonalcoholic fatty liver disease (NAFLD) is common but often goes undiagnosed, and therefore untreated. The presence of significant fibrosis is a key determinant of NAFLD progression, and liver steatosis has substantial cardiovascular implications. We aimed to determine the diagnostic accuracy of common noninvasive diagnostic tests for steatosis and fibrosis in the obese. We recruited 182 severely and morbidly obese individuals undergoing bariatric surgery (age 44 ± 12 years, body mass index 45.1 ± 8.3 kg/m2). Medical history, blood tests and liver biopsy were taken on the day of surgery. Serum steatosis and fibrosis scores were calculated. In a subgroup of patients, transient elastography with controlled attenuation parameter (TE/CAP) (n = 82) and proton magnetic resonance spectroscopy (1H-MRS) (n = 49) were performed. 1H-MRS had excellent diagnostic accuracy for steatosis, with strong correlation to steatosis (r = 0.647, p < 0.001), good AUROC (0.852, p = 0.001), sensitivity (81.3%) and specificity (87.5%). However, due to low feasibility in this cohort (65.3% success), this was substantially decreased with intention-to-diagnose analysis (sensitivity 50.0%, specificity 60.9%). CAP had good feasibility (8...Continue Reading

References

Jul 3, 2002·Annals of Internal Medicine·Daniele PratiGirolamo Sirchia
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Jan 24, 2007·AJR. American Journal of Roentgenology·Raul N UppotPeter R Mueller
Apr 9, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nathan A JohnsonJacob George
Jun 20, 2008·Atherosclerosis·Yasmin S HamiraniKhurram Nasir
Feb 27, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Don C RockeyUNKNOWN American Association for the Study of Liver Diseases
Oct 1, 2009·Obesity Surgery·Antônio Roberto Franchi TeixeiraLuiz Augusto Carneiro D'Albuquerque
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Norberto C Chavez-TapiaMisael Uribe
Jan 29, 2010·Postgraduate Medicine·Michael Cobble, Bradley Bale
May 25, 2010·Journal of Hepatology·Vlad RatziuGiulio Marchesini
Dec 16, 2010·Journal of Gastroenterology and Hepatology·Jayani ManchanayakeGeoffrey C Farrell
Feb 15, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elizabeth M BruntUNKNOWN NASH Clinical Research Network (CRN)
Apr 19, 2011·European Journal of Gastroenterology & Hepatology·Guillaume LassaillyPhilippe Mathurin
Sep 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert P MyersMagdy Elkashab
Jul 17, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sven M A FrancqueLuc Van Gaal
Dec 15, 2012·Endocrine Reviews·K H WilliamsS M Twigg
Mar 20, 2013·Nature Reviews. Gastroenterology & Hepatology·Quentin M AnsteeChristopher P Day
Nov 28, 2013·Clinics in Liver Disease·Zachary D Goodman
Jan 21, 2014·Cell·Evan D Rosen, Bruce M Spiegelman
Apr 16, 2014·The Lancet. Diabetes & Endocrinology·Hannele Yki-Järvinen
Aug 16, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mattias EkstedtRolf Hultcrantz
Oct 1, 2014·Alimentary Pharmacology & Therapeutics·L FedchukUNKNOWN LIDO Study Group
Dec 30, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Andrew A TaitanoMichel M Murr
Feb 26, 2015·Metabolic Syndrome and Related Disorders·Giovanni Targher, Christopher D Byrne
Apr 13, 2015·Journal of Hepatology·Shelley E KeatingNathan A Johnson
Apr 29, 2015·Gastroenterology·Guillaume LassaillyPhilippe Mathurin
Apr 29, 2015·Journal of Hepatology·Christopher D Byrne, Giovanni Targher
Aug 1, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sumeet K Asrani
Sep 18, 2015·Seminars in Liver Disease·Laurent Castera

❮ Previous
Next ❯

Citations

May 21, 2019·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Burcin BatmanSule Namli Koc
Dec 20, 2018·Obesity Surgery·Geraldine J OoiWendy A Brown
Mar 14, 2019·Gastroenterology Research and Practice·Patrick H AlizaiFlorian Ulmer
Feb 10, 2021·Digestive Diseases and Sciences·Richard K SterlingUNKNOWN HBV-HIV Cohort Study of the Hepatitis B Research Network
Feb 6, 2021·Canadian Journal of Gastroenterology & Hepatology·Changzhou CaiFeng Ji
May 16, 2021·Journal of Hepatology·Emmanuel Anandraj SelvarajUNKNOWN LITMUS Investigators

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
imaging techniques

Software Mentioned

Forn
SPSS
jMRUI
Excel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.