Evaluating genotoxicity associated with microcystin-LR and its risk to source water safety in Meiliang Bay, Taihu Lake

Environmental Toxicology
Jian-Yong WuJian-Hua Shen

Abstract

In recent years cyanobacteria blooms have become a severe problem in Taihu Lake, a large shallow eutrophic lake in China. Microcystins produced by certain genera of cyanobacteria can affect public health in this area because of their acute and chronic toxic effects. In this study, samples of cyanobacteria were collected and extracted by two solvent systems. The extracts were tested with three short-term genotoxicity assays, the ara test, the Ames test, and the SOS/umu test. In addition, temporal variation in the concentrations of microcystin-LR in the water samples was determined and monitored by an ELISA assay. Then the concentration of microcystin-LR in the drinking water was estimated. The risk of microcystin-LR exposure by drinking water was assessed according to tolerable daily intake (TDI). The three genotoxicity assays showed negative results regardless of the solvent system used, and there were clear inconsistencies in the spatiotemporal profiles of genotoxic potential and microcystin concentrations in Taihu Lake. Risk assessment showed that the drinking water from Taihu Lake was not safe from the end of July to the beginning of November because of a high concentration of microcystin-LR. Our study indicated the drinking...Continue Reading

References

May 1, 1983·Mutation Research·D M Maron, B N Ames
Jan 1, 1994·Scientific American·W W Carmichael
Jul 1, 1997·Toxicon : Official Journal of the International Society on Toxinology·K TsujiK Harada
May 20, 1999·Australian and New Zealand Journal of Public Health·L S PilottoR G Attewell
Apr 20, 2000·Reviews of Environmental Contamination and Toxicology·T N DuyD W Connell
Oct 12, 2004·Environmental Monitoring and Assessment·Jian-Yong WuJian-Hua Shen

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Citations

Sep 5, 2014·Canadian Journal of Microbiology·Chunli LiaoLinna Shan
Feb 1, 2011·Mutation Research·Bojana ZeguraMetka Filipič
Apr 13, 2010·Mutation Research·Lilianne Abramsson-ZetterbergRoland Mattsson
Dec 17, 2015·Environmental Science and Pollution Research International·Hary DemeyIngrid Bazin
Jul 16, 2013·TheScientificWorldJournal·Hiroshi SakaiHiroyuki Katayama

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