Evaluating mitochondrial DNA in cancer occurrence and development

Annals of the New York Academy of Sciences
Lijun ShenYidong Bai

Abstract

Abnormal mitochondria have long been hypothesized to be involved in tumorigenesis. Mitochondrial DNA (mtDNA) mutations have been found in various cancer cells, yet their role in tumorigenesis remains largely unknown. Our long-term goal is to understand the role of mtDNA polymorphism and mtDNA mutations in tumorigenesis. We focused on the role of the mtDNA haplogroup; a 4,977 bp common mtDNA deletion; mtDNA mutations in the main control region of mtDNA or displacement loop; and mtDNA heteroplasmy in cancer occurrence and cancer development. Our results indicate that qualitative and quantitative changes in mtDNA play an important role in cancer development.

References

Jan 1, 1978·Progress in Experimental Tumor Research·P L Pedersen
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M YonedaG Attardi
Jan 1, 1988·Annual Review of Cell Biology·G Attardi, G Schatz
Sep 1, 1988·Neurology·M ZevianiL P Rowland
Jan 1, 1985·International Review of Cytology·G Attardi
Apr 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·D A Clayton, J Vinograd
Apr 9, 1981·Nature·S AndersonI G Young
Oct 27, 1997·American Journal of Human Genetics·E WatsonH J Bandelt
Nov 7, 1998·Nature Genetics·K PolyakB Vogelstein
May 25, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A M LezzaM N Gadaleta
Aug 30, 2000·Lancet·D Hochhauser
Sep 8, 2000·BMJ : British Medical Journal·K McPhersonJ M Dixon
May 10, 2001·Mutation Research·J S PentaW C Copeland
Apr 30, 2002·International Journal of Cancer. Journal International Du Cancer·Kamila CzeneKari Hemminki
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth MamboDavid Sidransky
Feb 24, 1956·Science·O WARBURG
May 6, 2004·Annals of the New York Academy of Sciences·Masashi TanakaMiyuki Kurata
May 6, 2004·Annals of the New York Academy of Sciences·Yidong BaiGiuseppe Attardi
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Astrid LièvrePierre Laurent-Puig
Nov 21, 2007·Surgical Oncology·G DionigiR Dionigi
Jul 17, 2008·Gut·J J Y SungUNKNOWN Asia Pacific Working Group on Colorectal Cancer
Oct 15, 2008·Cancer·Gordon F SchwartzUNKNOWN Consensus Conference Committee The International Consensus Conference Committee
Apr 1, 2009·International Journal of Molecular Sciences·Hsin-Chen Lee, Yau-Huei Wei
May 26, 2009·Biochimica Et Biophysica Acta·Zhinan DingYidong Bai
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Aug 4, 2009·Biochimica Et Biophysica Acta·Yewei MaLee-Jun C Wong
Jan 20, 2010·Journal of Bioenergetics and Biomembranes·Katarína SmolkováRodrigue Rossignol

❮ Previous
Next ❯

Citations

Aug 26, 2011·Journal of Human Genetics·Tao ChenWeiwei Zhao
Jan 1, 2014·Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis·P CzarnyJ P Szaflik
Feb 24, 2015·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Xian-Li MengNing-Min Zhao
Jan 31, 2012·Mechanisms of Ageing and Development·Sébastien P GendronPatrick J Rochette
Aug 2, 2011·Biotechnology Advances·F ChiaradonnaL Alberghina
Feb 22, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J VerineA Janin
Jan 5, 2014·Acta Neuropathologica Communications·Ka Yu YeungJustin C St John
Jul 15, 2015·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Leila Zabihi DibaMassoud Houshmand
Sep 26, 2013·Radiation Research·Steven B ZhangPaul Okunieff
Dec 3, 2014·Brain Research·Adam NagyBernadette Kalman
Nov 16, 2017·International Journal of Molecular Sciences·Carmen W H ChanMary M Y Waye
Sep 13, 2018·Journal of Cellular Biochemistry·Maryam GholinezhadAli Bidmeshkipour
Apr 5, 2019·Journal of Cellular Biochemistry·Azza ElamirShaimaa E Ghazy
Oct 13, 2011·The American Journal of Surgical Pathology·Eleonora DuregonMauro Papotti
Nov 3, 2017·Oxidative Medicine and Cellular Longevity·Huaibin ZhouHezhi Fang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.