Evaluating Neurocognitive Deficits in Patients With Multiple Sclerosis Via a Brief Neuropsychological Approach

Applied Neuropsychology. Adult
Andrew DavisChristopher Randolph

Abstract

Recent research demonstrates neurocognitive deficits are present early in the sequelae of multiple sclerosis (MS). This is an important consideration given the functional activities of daily living, such as employment, that can be impacted by neurocognitive dysfunction. This study investigated the utility of a brief neuropsychological battery, the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), to evaluate neurocognitive deficits in patients with MS and to examine the relationship between a measure of functional disability (Expanded Disability Status Scale [EDSS]) and the RBANS. Participants were 49 patients with MS (Mage = 45.39 years) who completed the RBANS as part of a neuropsychological assessment and 49 demographically matched healthy controls (Mage = 45.39 years). Multivariate analysis of variance revealed that the two groups differed on the RBANS. Descriptive discriminant analysis indicated the groups differed on domains of attention, language, immediate memory, and delayed memory. EDSS scores were a good predictor of neurocognitive dysfunction in patients with advanced disability but not for patients with mild disability. The RBANS seems to be effective in identifying cognitive dysfunction i...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Dec 9, 1998·Journal of Clinical and Experimental Neuropsychology·C RandolphT N Chase
Oct 3, 2002·Multiple Sclerosis : Clinical and Laboratory Research·R L AupperleS T Gontkovsky
May 13, 2003·Developmental Neuropsychology·Nicolas Le CarretColette Fabrigoule
Aug 4, 2004·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·William W Beatty
Mar 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·R J Siegert, D A Abernethy
May 23, 2006·BMC Neuroscience·Javier J Gonzalez-RosaGuillermo Izquierdo
Feb 1, 2007·Multiple Sclerosis : Clinical and Laboratory Research·J J KragtC H Polman
Sep 23, 2008·Multiple Sclerosis : Clinical and Laboratory Research·G KoutsisD Vassilopoulos
Nov 3, 2009·Journal of Clinical and Experimental Neuropsychology·Leigh J BeglingerJane S Paulsen
Apr 10, 2010·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Joy Humphreys ClarkSid E O'Bryant
Dec 24, 2010·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Allen AzizianLusine Khandanyan
Jul 2, 2011·Dementia and Geriatric Cognitive Disorders·Jørgen WagleKnut Engedal
Aug 26, 2011·Expert Review of Neurotherapeutics·Maria Pia Amato, Emilio Portaccio
Dec 19, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·T AntonelliE Granieri
Jan 9, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·B YamoutR H Habib
Jan 25, 2013·The Clinical Neuropsychologist·Tracie M Umaki, Robert L Denney
May 9, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Phil MooreNeil P Robertson
May 16, 2013·Brain Injury : [BI]·Sara M LippaJerome S Caroselli
Aug 24, 2013·The British Journal of Psychiatry : the Journal of Mental Science·Elizabeth WashbrookKapil Sayal
Sep 6, 2013·Work : a Journal of Prevention, Assessment, and Rehabilitation·Tresvil G PackJason R Bellaw

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Citations

Mar 18, 2016·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Laura A RabinWilliam B Barr
Oct 25, 2016·Brain and Cognition·Emmanuelle DagenaisPierre Duquette
Dec 5, 2018·Behavior Research Methods·David Trafimow, Hunter A Myüz
Jun 6, 2021·Neurophysiologie clinique = Clinical neurophysiology·Mohsen GholamiAbbas Rahimi Jaberi

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