Evaluating Newborns at Risk for Early-Onset Sepsis

Pediatric Clinics of North America
Pamela I Good, Thomas A Hooven

Abstract

Early-onset sepsis (EOS) is an important cause of neonatal morbidity. Despite extensive study, identifying at-risk newborns remains challenging, especially if they are initially well appearing. Existing official EOS recommendations suggest a conservative approach that likely results in overtreatment of a low-risk population. Recent studies indicate that more precise risk assessment and alternative management strategies could decrease the number of infants exposed to blood draws and antibiotics during evaluations for EOS. This article reviews existing guidelines and provides an overview of the Bayesian sepsis calculator and serial observation as an alternative to laboratory studies and empirical antibiotics.

Citations

Dec 19, 2019·Current Opinion in Pediatrics·Alberto BerardiAdam Frymoyer
Aug 2, 2020·NeoReviews·Augusto SolaUNKNOWN members of the 10th SIBEN Clinical Consensus
Dec 21, 2020·American Journal of Perinatology·Ligia Maria Suppo de Souza RugoloGary M Weiner
Jul 19, 2020·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Marcelo CardettiAugusto Sola
Mar 9, 2021·Seminars in Fetal & Neonatal Medicine·Noa FleissRichard A Polin
Sep 4, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jörn-Hendrik Weitkamp
Jul 10, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Sandra Salas GarciaJuan Diego Toledo
Sep 12, 2021·The Pediatric Infectious Disease Journal·Eleonora PontelloPaola Lago

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