Evaluating skin-protective materials against contact irritants and allergens. An in vivo screening human model

Contact Dermatitis
H ZhaiHoward I Maibach

Abstract

2 acute irritants and 1 allergen were selected: sodium lauryl sulfate (SLS) representative of irritant household and occupational contact dermatitis, the combination of ammonium hydroxide (NH4OH) and urea to simulate diaper dermatitis, and Rhus to evaluate the effect of model protective materials. The putative protective materials and vehicle were applied to both ventral forearms of 10 subjects in each group, according to a randomized code. Test materials were spread over a marked 2.0 cm2 area, massaged in, allowed to dry for 30 min, and reapplied with another 30 min drying period. The model irritants and allergen were then applied (0.025 ml) to an Al-test occlusive patch, which in turn was placed for 24 h over each of the 8 designated sites. Inflammation was scored according to a clinical scale 72 h post-application. Paraffin wax plus Acetulan in cetyl alcohol, and beeswax plus Acetulan in cetyl alcohol, markedly (p < 0.001) suppressed SLS irritation. Paraffin wax plus beeswax in cetyl alcohol, and Acetulan in cetyl alcohol reduced NH4OH and urea irritation (p < 0.05), paraffin wax in cetyl alcohol significantly (p < 0.01) decreasing Rhus allergic contact dermatitis. This model, provides an easy approach to screening protectan...Continue Reading

References

Jan 1, 1978·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·R R LauwerysH Roels
May 1, 1989·The British Journal of Dermatology·R MarksI Hamami
Aug 1, 1996·Contact Dermatitis·H Zhai, H I Maibach

❮ Previous
Next ❯

Citations

Dec 7, 2010·Therapeutic Delivery·Kalpana S PaudelAudra L Stinchcomb
Jul 16, 2014·Clinics in Dermatology·Christopher KlunkKaren Wiss
Nov 11, 2014·Dermatitis : Contact, Atopic, Occupational, Drug·Monica CorazzaAlessandro Borghi
Jan 17, 2002·Advances in Skin & Wound Care·H N Mayrovitz, N Sims
Feb 23, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Christian Surber, Eric W Smith
Feb 15, 2008·The American Journal of Emergency Medicine·Michael A MillerMarc E Levsky
Nov 22, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Peter J FroschBeate Grunenberg
Oct 4, 2007·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Jochen BraschAxel Schnuch
Oct 25, 2007·Expert Opinion on Pharmacotherapy·Sharon E Jacob, Mari Paz Castanedo-Tardan
Nov 25, 2014·Archives of Dermatological Research·J LarnerR P Chilcott
Jun 29, 2005·International Journal of Toxicology·UNKNOWN Cosmetic Ingredient Review Expert Panel
Jan 21, 2006·International Journal of Toxicology
Dec 1, 2006·Journal of Cosmetic Dermatology·H Zhai, H I Maibach
Aug 26, 2006·Contact Dermatitis·Miki Yokota, Howard I Maibach
Jun 11, 2008·Archives of Dermatological Research·Man-Jau ChangTsong-Min Chang
May 27, 2011·Archives of Gynecology and Obstetrics·Mehrnaz GeranmayehAbbas Mehran
Sep 12, 2017·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Zunjia WenMeifen Shen
May 23, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Manigé FartaschSibylle Schliemann
Apr 10, 2003·International Archives of Occupational and Environmental Health·Birgitta Kütting, Hans Drexler
Jan 22, 2003·Contact Dermatitis·Tove Agner, Elisabeth Held

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Tamer GunesTakashi Hashimoto
Chemical & Pharmaceutical Bulletin
Tomoko FujimotoKakuji Tojo
Dermatology : International Journal for Clinical and Investigative Dermatology
W Wigger-Alberti, P Elsner
© 2022 Meta ULC. All rights reserved