Evaluating Spatial Associations in Inpatient Deaths Between Organ Procurement Organizations.

Transplantation Direct
Joel T Adler, Tanujit Dey

Abstract

To improve the measurement of organ procurement organization (OPO) performance, the Center for Medicare and Medicaid Services recently proposed using inpatient deaths defined as the eligible pool of organ donors within an OPO as patients 75 years or younger that died from any cause that would not preclude donation. To account for the geographic variation in OPO performance and organ availability across the United States, we utilized spatial analysis to appraise the newly proposed metric of inpatient deaths. Using spatial clustering that accounts for geographic relationships between Organ Procurement Organizations, the top 5 causes of donation-eligible death, and inpatient deaths, we identified 4 unique OPO clusters. Each group had a distinct demographic composition, cause of death, and inpatient death pattern. In multivariate analysis accounting for these geographic relationships, the spatial clusters remained significantly associated with the outcome of inpatient deaths (P < 0.001) and were the best-fitting model compared with models without the spatial clusters; this suggests that further risk adjustment of inpatient deaths should include these geographic considerations. This approach provides not only a manner to assess dono...Continue Reading

References

Jan 10, 2008·JAMA : the Journal of the American Medical Association·David A AxelrodRobert M Merion
Apr 23, 2009·JAMA : the Journal of the American Medical Association·Marcello TonelliJohn Gill
Aug 28, 2010·Clinical Journal of the American Society of Nephrology : CJASN·David A AxelrodKrista L Lentine
Jan 6, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sommer E GentryDorry L Segev
Jun 2, 2015·JAMA Internal Medicine·Paula ChatterjeeErika G Martin
Jun 3, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R Luskin, H Nathan
Jul 25, 2015·Journal of the American College of Surgeons·Joel T AdlerLouis L Nguyen
Sep 10, 2015·The Milbank Quarterly·Keren LadinJames R Rodrigue
May 22, 2016·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Michael ReibelJeff Koertzen
Dec 16, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K P CroomeC B Taner
Jan 19, 2018·Transplantation·David S GoldbergLaura Siminoff
Mar 30, 2018·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Laura A SiminoffTeresa J Shafer
Feb 28, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A K IsraniB L Kasiske
Apr 14, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Robert M CannonMalay B Shah
May 16, 2019·Current Opinion in Organ Transplantation·Raymond J Lynch, Rachel E Patzer
Jun 15, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·David GoldbergRaymond Lynch
Mar 12, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jon J SnyderBertram L Kasiske

❮ Previous
Next ❯

Software Mentioned

R
QGIS
ClustGeo
R package ClustGeo
GeoDa

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Akinlolu O OjoDavid M Dickinson
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
David GoldbergRaymond Lynch
Journal of Transplant Coordination : Official Publication of the North American Transplant Coordinators Organization (NATCO)
T J ShaferC A Andrews
© 2021 Meta ULC. All rights reserved