Abstract
Biosynthesis of gold nanoparticles of distinct geometric shapes with highly functional protein coats without additional capping steps is rarely reported. This study describes green synthesis of protein-coated gold nanoparticles for the first time from the edible, mycorrhizal fungus Tricholoma crassum (Berk.) Sacc. The nanoparticles were of the size range 5-25 nm and of different shapes. Spectroscopic analysis showed red shift of the absorption maxima with longer reaction period during production and blue shift with increase in pH. These were characterized with spectroscopy, SEM, TEM, AFM, XRD, and DLS. The particle size could be altered by changing synthesis parameters. These had potent antimicrobial activity against bacteria, fungi, and multi-drug-resistant pathogenic bacteria. These also had inhibitory effect on the growth kinetics of bacteria and germination of fungal spores. These showed apoptotic properties on eukaryotic cells when tested with comet assays. Moreover, the particles are capped with a natural 40 kDa protein which was utilized as attachment sites for genes to be delivered into sarcoma cancer cells. The present work also attempted at optimizing safe dosage of these nanoparticles using hemolysis assays, for appl...Continue Reading
References
Sep 15, 2000·Mutation Research·T GichnerM J Plewa
May 29, 2009·Molecular Pharmaceutics·Jaya JainKishore M Paknikar
Jul 21, 2011·Journal of Drug Delivery·Tomoko ItoMakoto Otsuka
Mar 21, 2012·Nano Letters·Jack J MockDavid R Smith
Nov 29, 2012·ACS Nano·Ana Sánchez-IglesiasLuis M Liz-Marzán
Apr 5, 2013·Environmental Science & Technology·Stacey M LouieGregory V Lowry
Jun 22, 2013·Advanced Materials·Yu Jin ShinMark C Hersam
Aug 6, 2013·ACS Sustainable Chemistry & Engineering·Sergio Dominguez-MedinaStephan Link
Aug 21, 2013·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Ghada H Shaker, Nahla A Melake
Sep 7, 2013·PloS One·Victor BanerjeeAnirban Bhunia
Feb 8, 2014·Theranostics·Lian JinNongyue He
Mar 29, 2014·Nano Letters·Ronnie H FangLiangfang Zhang
Apr 15, 2014·Journal of the American Chemical Society·Longyan LiaoJeremiah A Johnson
Aug 13, 2014·Nanoscale Research Letters·Supriyo ChowdhurySurekha Kundu
Aug 28, 2014·IEEE Transactions on Nanobioscience·Pritish R TidkeMahendra Rai
Oct 2, 2014·Journal of Hazardous Materials·Razi AhmadMeryam Sardar
Jan 7, 2015·Journal of Hazardous Materials·Indarchand R GuptaMahendra Rai
May 11, 2015·Glycoconjugate Journal·Nam D PhamJennifer J Kohler
Sep 12, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Daniele R NogueiraClarice M B Rolim
Feb 26, 2016·Nanoscale Research Letters·Khwaja Salahuddin Siddiqi, Azamal Husen
Mar 20, 2016·Enzyme and Microbial Technology·Priyanka SinghDeok Chun Yang
Apr 26, 2016·Advanced Healthcare Materials·Basmah A OthmanAlexandra E Porter
Jun 9, 2016·Scientific Reports·Madhuree KumariChandra Shekhar Nautiyal
Jul 31, 2016·Carbohydrate Polymers·M Sathiyabama, R Parthasarathy
Oct 27, 2016·PeerJ·Niels HadrupHenrik L Frandsen
Jan 25, 2017·Microbial Pathogenesis·Balasubramanian MalaikozhundanGiovanni Benelli
May 10, 2017·Advances in Colloid and Interface Science·Marion Mathelié-GuinletTouria Cohen-Bouhacina
Citations
Oct 18, 2019·Medical & Biological Engineering & Computing·Xiaoli RuanZicheng Cao
Oct 1, 2018·Nanoscale Research Letters·Mei-Xia ZhaoZhi-Qiang Zhang
Dec 15, 2019·Antibiotics·Abdulkader MasriRuqaiyyah Siddiqui
Oct 26, 2018·Journal of Peptide Science : an Official Publication of the European Peptide Society·Jafar JalaeiMehdi Fazeli
Jan 18, 2020·Nanoscale Research Letters·Mengjun ShuMin Zeng
Feb 11, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea RónaváriMonika Kiricsi
May 1, 2021·Nanoscale Research Letters·Mengjun ShuLin Xu
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Xing Yue XuYeon-Ju Kim
Jul 4, 2021·Ecotoxicology and Environmental Safety·Kanika KhannaParvaiz Ahmad
Aug 28, 2021·Environmental Research·Surya SudheerSivakumar Manickam