PMID: 8949646Sep 1, 1996Paper

Evaluating the antioxidant potential of new treatments for inflammatory bowel disease using a rat model of colitis

Gut
A D MillarD R Blake

Abstract

Reactive oxygen species may mediate tissue injury in inflammatory bowel disease. Aminosalicylates have antioxidant activity and the antioxidants, superoxide dismutase and allopurinol, are of reported benefit in inflammatory bowel disease. To develop a convenient technique for testing the antioxidant potential of standard and novel therapeutic agents for use in inflammatory bowel disease. Amplified chemiluminescence was used to measure reactive oxygen species production by colonic biopsy specimens from rats with acetic acid induced colitis and to assess the in vitro effect of conventional antioxidants, standard therapies and proposed novel therapies for inflammatory bowel disease. The model was validated by demonstrating that the profile of effects on chemiluminescence of acetic acid induced colitis biopsy specimens given by conventional antioxidants (sodium azide, catalase, copper-zinc superoxide dismutase, dimethyl sulphoxide, N-acetylcysteine and ascorbate) and standard therapies (5-aminosalicylate and hydrocortisone) resembled that previously reported using biopsy specimens from ulcerative colitis. Human recombinant manganese superoxide dismutase did not alter chemiluminescence. Two novel compounds, LY231617 (10 mM) and amfl...Continue Reading

References

Mar 17, 1975·Biochemical and Biophysical Research Communications·M Nishikimi
Jan 1, 1978·Digestion·B R MacPherson, C J Pfeiffer
Jan 1, 1992·Free Radical Biology & Medicine·C F Babbs
Aug 1, 1992·Histopathology·A P DhillonR E Pounder
May 1, 1992·Diseases of the Colon and Rectum·K E LevinM E Pezim
Jan 1, 1992·Journal of Dermatological Science·L GordonB A Gilchrest
Jan 1, 1992·Free Radical Research Communications·A Haas, W Goebel
Jan 1, 1991·Free Radical Research Communications·B ParizadaA Nimrod
Nov 1, 1991·Journal of Leukocyte Biology·M SuzukiD N Granger
Oct 1, 1991·Journal of the Royal Society of Health·O I AruomaB Halliwell
Jan 23, 1991·Biochimica Et Biophysica Acta·T R GreenK L Pratt
Jan 1, 1991·Free Radical Research Communications·J EmeritA Thuillier
Jan 1, 1991·Free Radical Research Communications·M GoreckiA Nimrod
Dec 1, 1990·Inflammation·M B GrishamE A Deitch
Oct 15, 1989·The Biochemical Journal·D RiendeauD J Nathaniel
Jan 1, 1989·Annals of the Rheumatic Diseases·H L Nurcombe, S W Edwards
Jun 1, 1989·The Journal of Clinical Investigation·I Maridonneau-PariniF Russo-Marie
Apr 1, 1989·Digestive Diseases and Sciences·S H PettitM H Irving
Sep 1, 1989·Gastrointestinal Endoscopy·J J Bilotta, J D Waye
Jan 1, 1987·The Journal of Pharmacy and Pharmacology·B Lehuu, P B Curtis-Prior
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Aug 1, 1985·Archives of Biochemistry and Biophysics·J Blum, I Fridovich
May 1, 1993·Stroke; a Journal of Cerebral Circulation·J A ClemensJ A Panetta

❮ Previous
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Citations

Oct 6, 2005·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Tian YangWei Qian
Nov 25, 2006·International Journal of Colorectal Disease·Murat GirişGülçin Aykaç Toker
Aug 24, 2006·Digestive Diseases and Sciences·Ahmet NecefliGülçin Toker
Sep 8, 2006·Digestive Diseases and Sciences·Cumhur DeğerGülçin Toker
Dec 8, 2006·Digestive Diseases and Sciences·M A PélissierP Pochart
Sep 24, 2009·Biological Trace Element Research·Muharrem BitirenAli Uzunkoy
Nov 15, 2001·General Pharmacology·V Nosál'ováV Bauer
May 17, 2003·Toxicology Letters·Afaf A Mahgoub
Apr 23, 2003·Free Radical Biology & Medicine·Seiko NarushimaDaniel J Berg
Sep 6, 2000·Alimentary Pharmacology & Therapeutics·A D MillarD R Blake
Feb 28, 2002·Alimentary Pharmacology & Therapeutics·L LangmeadD S Rampton
Oct 5, 2007·Journal of Gastroenterology and Hepatology·Yeşim ErbilGülçin Aykaç Toker
Feb 15, 2000·Gut·D M McCafferty
May 13, 2005·The Tohoku Journal of Experimental Medicine·Ali CetinkayaMehmet Akif Buyukbese
May 27, 2010·Indian Journal of Pharmaceutical Sciences·M KhushtarUma Bhandari
Feb 14, 2014·The British Journal of Nutrition·Claire ZhangKrista A Power
Mar 30, 2013·International Immunopharmacology·Narayanan Kannan, Chandrasekharan Guruvayoorappan
Jul 6, 2013·Digestive Diseases and Sciences·Carlos Augusto Real MartinezJosé Aires Pereira
Aug 30, 2008·Digestive Diseases and Sciences·Turhan DostMustafa Birincioglu
Nov 7, 2009·Digestive Diseases and Sciences·Daniel C DaminGilberto Schwartsmann
Nov 3, 2010·Digestive Diseases and Sciences·Caroline CaltabianoCarlos Augusto Real Martinez
Jan 19, 2012·International Reviews of Immunology·Udai P SinghPrakash S Nagarkatti
Mar 11, 2015·Immunopharmacology and Immunotoxicology·Engy M El MorsyMaha A E Ahmed
May 30, 1998·Scandinavian Journal of Gastroenterology·A MehtaN K Ganguly
Aug 13, 2011·Free Radical Research·Magdalena L Circu, Tak Yee Aw
Oct 18, 2016·Drug Delivery·Figen EsiringüSeda M Sarı Kılıçaslan
Jun 19, 2013·The Journal of Surgical Research·Jinghu HeQiang Wang

❮ Previous
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