Evaluating the comparability of gene expression in blood and brain

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Patrick F SullivanCharles M Perou

Abstract

The availability of an accessible tissue whose gene expression profile is similar to more inaccessible CNS tissues has the potential to advance research in neuropsychiatric disorders. We conducted secondary data analysis of transcriptional profiling of 79 human tissues for 33,698 genes using the Affymetrix U133A microarray augmented with a custom microarray (Affymetrix GNF1H), which were produced by the Genomics Institute of the Novartis Research Foundation (http://symatlas.gnf.org). Our analyses suggested that: (a) on a transcriptome level, whole blood shares significant gene expression similarities with multiple CNS tissues; (b) the median non-parametric correlation between transcripts present in both whole blood and CNS was around 0.5; (c) this correlation of 0.5 was intermediate relative to all tissues in the Novartis data set--less than for the maximum achievable value of 0.85, less than a set of immune tissues (0.64), comparable to a heterogeneous set of somatic tissues (0.57) but greater than muscle (0.48) and peripheral nervous system tissues (0.36); (d) about half of a set of candidate genes relevant to schizophrenia were expressed in both whole blood and prefrontal cortex; and (e) the expression levels of many classes...Continue Reading

References

Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Aug 30, 2000·Nature·C M PerouD Botstein
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y HakakA A Fienberg
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Sep 29, 2001·Brain Research Bulletin·M P VawterK G Becker
May 25, 2002·Human Molecular Genetics·Kodavali V ChowdariVishwajit L Nimgaonkar
Jul 2, 2002·Archives of General Psychiatry·Scott E HembyJames H Eberwine
Oct 5, 2002·Schizophrenia Research·Marquis P VawterWilliam J Freed
Nov 28, 2002·Nature Genetics·John Quackenbush
Sep 19, 2003·Lancet·Dmitri TkachevSabine Bahn
Dec 19, 2003·Nucleic Acids Research·M A HarrisUNKNOWN Gene Ontology Consortium
Jan 27, 2004·Schizophrenia Research·Marquis P VawterWilliam Byerley
Apr 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Andrew I SuJohn B Hogenesch
Apr 20, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anatoliy GladkevichJakob Korf
May 4, 2004·Nature Biotechnology·George L Gabor Miklos, Ryszard Maleszka
Aug 31, 2004·Journal of Neuroscience Research·Christopher AstonBoris P Sokolov
Nov 16, 2004·Annals of the New York Academy of Sciences·Tetsuji SugaiHiroyuki Nawa
Jan 13, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ming T TsuangC C Liew
Mar 30, 2005·American Journal of Physical Anthropology·Amy Sullivan
Jun 11, 2005·Schizophrenia Research·Lise RiouxSteven Edward Arnold
Jul 22, 2005·PLoS Medicine·Patrick F Sullivan
Oct 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stephen J GlattMing T Tsuang

❮ Previous
Next ❯

Citations

Sep 23, 2008·Molecular Diagnosis & Therapy·Anders Lönneborg
Nov 23, 2010·Psychopharmacology·Karen D ErscheEdward T Bullmore
May 18, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Mary E WinnNicholas J Schork
Nov 12, 2010·Journal of Neural Transmission·Edna GrünblattPeter Riederer
Apr 14, 2009·Current Atherosclerosis Reports·Myriam Fornage
Apr 29, 2010·Current Psychiatry Reports·Divya MehtaElisabeth B Binder
Mar 10, 2012·Journal of Molecular Neuroscience : MN·Juan A GallegoAnil K Malhotra
May 9, 2012·Attention Deficit and Hyperactivity Disorders·Edna GrünblattAngelika Schmitt
Mar 19, 2014·European Psychiatry : the Journal of the Association of European Psychiatrists·P GrantJ Hennig
Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ilan HalperinSilvia A Mandel
Jul 29, 2011·Expert Reviews in Molecular Medicine·Benjamin Pickard
Apr 23, 2011·Journal of Human Genetics·Hidenaga YamamoriMasatoshi Takeda
Jul 8, 2009·Molecular Psychiatry·R H SegmanD Hochner-Celnikier
Feb 19, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Annamaria CattaneoMassimo Gennarelli
Apr 2, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Abigail PolterRichard S Jope
Jan 13, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andreas MenkeElisabeth B Binder
Feb 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Takashi MoriharaMasatoshi Takeda
Dec 14, 2011·Briefings in Functional Genomics·Marquis P VawterFabio Macciardi
Oct 24, 2006·Epilepsia·Frank R SharpTracy A Glauser
Apr 26, 2008·Epilepsia·Ingo HelbigNicholas K Hayward
Oct 23, 2010·Stroke; a Journal of Cerebral Circulation·Huichun XuCharles S Decarli
Oct 22, 2010·BMC Genomics·Chaochao CaiSteve Horvath
Feb 7, 2013·BMC Medicine·Nilay HepgulCarmine M Pariante
Jun 2, 2012·Molecular Neurodegeneration·Leonid MolochnikovSilvia A Mandel
Jul 3, 2013·Molecular Autism·Wei-Hsien ChienChia-Hsiang Chen
Jul 31, 2013·Genome Biology·Daniel GlassTim D Spector
Jan 17, 2012·PloS One·Willemijn M PasstoorsP Eline Slagboom

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
S J GlattM T Tsuang
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
M T TsuangC C Liew
Progress in Neuro-psychopharmacology & Biological Psychiatry
Anatoliy GladkevichJakob Korf
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
F A MiddletonMichele T Pato
© 2021 Meta ULC. All rights reserved