Evaluating the cost per child vaccinated with full versus fractional-dose inactivated poliovirus vaccine

Vaccine: X
Mercy MvunduraCourtney Jarrahian

Abstract

Inactivated poliovirus vaccine (IPV) shortages and evidence of improved immunogenicity of two intradermal (ID) fractional IPV (fIPV) doses compared with one full intramuscular dose led to recommendations for fIPV delivery. To provide evidence on the economics of fIPV, we estimated the cost per child vaccinated using full-dose IPV compared with fIPV in routine and campaign settings. We evaluated the impact on costs of alternative devices facilitating ID administration, vaccine vial sizes, and prices. We used an Excel-based model to estimate the commodity and delivery costs for providing IPV. Commodity costs included vaccine price per dose adjusted for wastage, prices for vaccine administration devices, and safety boxes. Delivery costs included storage costs at each level of the supply chain, transport costs for commodities between levels, and human resource costs for vaccine administration. Model inputs were obtained from various databases and published literature. All costs are reported in 2018 US dollars. In both campaign and routine settings, fIPV had a lower cost per child vaccinated than full dosing, despite the assumed higher vaccine wastage with fIPV in routine settings, and even when novel ID administration devices were ...Continue Reading

Citations

Jul 10, 2020·Risk Analysis : an Official Publication of the Society for Risk Analysis·Kimberly M Thompson, Dominika A Kalkowska
Aug 4, 2020·Expert Review of Vaccines·Kimberly M Thompson, Dominika A Kalkowska

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SAGE
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Excel

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