Evaluating the cost utility of racecadotril for the treatment of acute watery diarrhea in children: the RAWD model.

ClinicoEconomics and Outcomes Research : CEOR
Tamlyn Anne RautenbergRick Aultman

Abstract

The safety and efficacy of racecadotril to treat acute watery diarrhea (AWD) in children is well established, however its cost effectiveness for infants and children in Europe has not yet been determined. To evaluate the cost utility of racecadotril adjuvant with oral rehydration solution (ORS) compared to ORS alone for the treatment of AWD in children younger than 5 years old. The analysis is performed from a United Kingdom National Health Service (NHS) perspective. A decision tree model has been developed in Microsoft(®) Excel. The model is populated with the best available evidence. Deterministic and probabilistic sensitivity analyses (PSA) have been performed. Health effects are measured as quality-adjusted life years (QALYs) and the model output is cost (2011 GBP) per QALY. The uncertainty in the primary outcome is explored by probabilistic analysis using 1000 iterations of a Monte Carlo simulation. Deterministic analysis results in a total incremental cost of -£379 in favor of racecadotril and a total incremental QALY gain in favor of racecadotril of +0.0008. The observed cost savings with racecadotril arise from the reduction in primary care reconsultation and secondary referral. The difference in QALYs is largely attrib...Continue Reading

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Citations

Dec 31, 2015·Archives of Disease in Childhood·Morris Gordon, Anthony Akobeng
Jun 28, 2014·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Nick AdlardEmma Frew
Apr 24, 2014·PloS One·Olivia ValenzuelaLihua Xiao
Dec 4, 2019·Journal of Pediatric Gastroenterology and Nutrition·Corina PienarNikhil Thapar
Dec 21, 2019·The Cochrane Database of Systematic Reviews·Yi LiangJin Wen
Jan 25, 2020·Journal of Pediatric Gastroenterology and Nutrition·Corina PienarNikhil Thapar
Dec 1, 2012·Current Opinion in Gastroenterology·Eugenia BruzzeseAlfredo Guarino
Oct 21, 2016·Human Vaccines & Immunotherapeutics·Shu-Ling HoshiIchiro Okubo

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Software Mentioned

Excel

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