Evaluating the cytotoxicity of tin dioxide nanofibers

Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
Ashley S ReynoldsWorlanyo E Gato

Abstract

Tin dioxide nanofibers (SnDNFs) are small fibers that have many applications. Tin dioxide nanofibers can be used in cosmetics, solar cells, toxic gas release sensors, and air pollution control. To date there have been few studies on the cytotoxicity of SnDNFs. The goal of this research is to determine if electrospun SnDNFs are toxic in a lung cancer cell line (A549). Considering the nano-scale size of the fibers, they can easily be inhaled and enter the pulmonary system and cause toxic effects in the lung. Occupational exposure to SnDNFs has been linked to pulmonary disease, making the A549 cell line important in this study. Nanofiber toxicity can vary based upon the characteristics of the fibers. Smaller nanofibers have been shown to have more toxic effects than their larger counterparts. The synthesized SnDNFs were characterized using SEM, Raman spectroscopy, and powder X-ray diffractometer (PXRD). SEM images showed the fibers to be 200-300 nm in diameter. Raman spectroscopy and PXRD indicated that the fibers were in the rutile phase. After quantifying the SnDNFs, the fibers were introduced to A549 cells at concentrations ranging from 0.02-500 µg mL-1 and incubated at 37°C. These cells were quantified with the MTT assay to me...Continue Reading

References

Dec 22, 2006·PloS One·Maria C AlmeidaAndrej A Romanovsky
Jan 30, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Dominique LisonBice Fubini
Jul 28, 2006·Nanotechnology·W E Teo, S Ramakrishna
Nov 27, 2010·Colloids and Surfaces. B, Biointerfaces·Elena MavropoulosAlexandre M Rossi
Jul 31, 2013·Oncoimmunology·Saskia Jam SantegoetsTanja D de Gruijl
Jul 16, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·V K Vidhu, Daizy Philip
Nov 21, 2014·Applied Biochemistry and Biotechnology·Selvaraj Mohana RoopanKrishnamurthy Suthindhiran
Jul 6, 2015·Journal of Photochemistry and Photobiology. B, Biology·Alan Man Ching NgHung Kay Lee
Sep 18, 2016·Chemosphere·Adriana Chávez-CalderónAntonia Luna-Velasco
Dec 5, 2016·Journal of Photochemistry and Photobiology. B, Biology·Sai Kumar TamminaNandita Dasgupta

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Methods Mentioned

BETA
x-ray diffraction
PCR
scanning electron microscopy
electrophoresis

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