Evaluating the donor pool: impact of using hearts from donors over the age of 49 years

Transplant International : Official Journal of the European Society for Organ Transplantation
P MercerJ Parameshwar

Abstract

The shortage of hearts for transplantation has led to the use of organs from older donors in many centres. Despite the lack of coronary angiography on potential organ donors, hearts from carefully selected donors over 49 years of age have been used at this centre since 1988. In the study reported here looked at the impact of this strategy on morbidity and mortality. Between May 1988 and August 1996, 400 first heart transplants were performed, 35 recipients (31 male, 4 female; age 51 +/- 5.9 years) received hearts from donors over 49 years of age (group 1) while 365 (310 male, 55 female; age 49 +/- 9.7 years) had younger donors (group 2). The mean ischaemic time was 189 min (+/- 63.1) in group 1 and 180 min (+/- 59.2) in group 2 (n.s.). The main aetiology of heart failure in groups 1 and 2 was coronary artery disease in 46% and 51%, and dilated cardiomyopathy in 40% and 45% respectively (n.s.). There were no differences in the duration of stay on the intensive care unit or in hospital between the groups. One-year survival was 79% in group 1 and 82% in group 2 (n.s.) and actuarial 5-year survival 69% and 67%, respectively. Six patients in group 1 (17%) and 45 patients in group 2 (12%) died in the first 3 months; of these primary ...Continue Reading

References

Jun 23, 1984·British Medical Journal·T A EnglishD Wheeldon
Mar 1, 1995·The Annals of Thoracic Surgery·M IbrahimW J Keon
Oct 25, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J D HosenpudR J Novick

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Citations

Jul 16, 2010·Wiener klinische Wochenschrift·Daniel HöferUNKNOWN Arbeitskreis "Herztransplantation" der Österreichischen Gesellschaft für Kardiologie
Aug 10, 2000·The New England Journal of Medicine·B Gridelli, G Remuzzi
Feb 21, 2002·AACN Clinical Issues·Linda S BaasLynne E Wagoner
Jun 28, 2012·International Anesthesiology Clinics·Kathirvel Subramaniam

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