Evaluating the effectiveness of infliximab on perianal fistulizing Crohn's disease by magnetic resonance imaging

Gastroenterology Report
Xiaohan YanZhihua Ran

Abstract

Data on the radiologic evaluation of perianal fistulizing Crohn's disease (PFCD) naïve to anti-tumor necrosis factor therapy are scarce, especially in Asian populations. We assessed the effectiveness of infliximab (IFX) on PFCD and explored predictors of 'deep remission' based on clinical and radiologic assessments. Patients with Crohn's disease and active anal fistulas attending our care center for IFX therapy were prospectively enrolled. Each patient underwent clinical examination according to the Fistula Drainage Assessment Index, endoscopy for assessment of Crohn's Disease Activity Index (CDAI) and Perianal Crohn's Disease Activity Index (PCDAI), magnetic resonance imaging (MRI) to determine Van Assche score and Ng score, and laboratory tests up to 2 weeks prior to the start of and up to 2 weeks after the sixth IFX therapy (Week 32). Among 38 patients treated with IFX, 52.6% achieved clinical remission based on the Fistula Drainage Assessment Index and 42.1% achieved deep remission based on Ng score. Van Assche score (from 14.5 ± 4.26 to 7.36 ± 7.53), CDAI (from 170 ± 92 to 71 ± 69) and PCDAI (from 7.45 ± 2.65 to 2.44 ± 3.20) decreased significantly after six IFX treatments. The only predictor of deep remission was simple f...Continue Reading

References

Dec 1, 1993·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J BreidthardtL Mehlburger
Nov 1, 1995·Gut·F MakowiecM Starlinger
May 6, 1999·The New England Journal of Medicine·D H PresentS J van Deventer
Nov 30, 2000·The American Journal of Gastroenterology·S KugathasanD G Binion
Mar 23, 2002·Gastroenterology·David A SchwartzWilliam J Sandborn
Jun 6, 2002·Lancet·Stephen B HanauerUNKNOWN ACCENT I Study Group
May 21, 2003·Alimentary Pharmacology & Therapeutics·A ViscidoR Caprilli
Aug 28, 2003·Alimentary Pharmacology & Therapeutics·P LionettiA Barabino
Dec 5, 2003·Alimentary Pharmacology & Therapeutics·C DejacoW Reinisch
Feb 27, 2004·The New England Journal of Medicine·Bruce E SandsSander J van Deventer
Mar 15, 2006·Gastroenterology·Laurent BeaugerieJacques Cosnes
Aug 15, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Linda Y TangCharles N Bernstein
Aug 28, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S B Ingle, E V Loftus
Nov 9, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Konstantinos KarmirisGert Van Assche
Nov 19, 2010·Alimentary Pharmacology & Therapeutics·P J TozerA L Hart
Dec 3, 2010·Journal of Crohn's & Colitis·Gert Van AsscheUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Jan 10, 2012·Inflammatory Bowel Diseases·Phil TozerAilsa Hart
Sep 6, 2013·Pediatric Radiology·Anuradha Shenoy-BhangleMichael S Gee
Jun 22, 2014·Gut·Krisztina B GecseUNKNOWN World Gastroenterology Organization International Organisation for Inflammatory Bowel Diseases IOIBD European Society of Col
Jul 6, 2014·International Journal of Colorectal Disease·Giovanni MaconiGabriella Ba
Aug 28, 2014·Inflammatory Bowel Diseases·Ilse MolendijkC Janneke van der Woude
Dec 9, 2014·Journal of Clinical Gastroenterology·Carlos Castaño-MillaJavier P Gisbert
Feb 11, 2015·World Journal of Gastroenterology : WJG·Manuela MarzoLuisa Guidi
Mar 10, 2015·Postgraduate Medicine·Anna C JuncadellaAmar R Deshpande
Sep 5, 2015·Mediators of Inflammation·Luz María MedranoElena Urcelay
Jan 10, 2017·Techniques in Coloproctology·J RayenT Eglinton
Jul 12, 2017·World Journal of Gastroenterology : WJG·Lucie ThomassinCéline Savoye-Collet

❮ Previous
Next ❯

Citations

Oct 23, 2019·Alimentary Pharmacology & Therapeutics·Joyce Wing Yan MakSiew C Ng

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.