Evaluating the effects of immediate application of negative pressure therapy after decompression from abdominal compartment syndrome in an experimental porcine model

European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society
S K ShahCharles S Cox

Abstract

The purpose of this large-animal study was to assess the safety and effects of negative pressure therapy (NPT) when used as temporary abdominal closure in the immediate post-decompression period after abdominal compartment syndrome (ACS). Using a hemorrhagic shock/resuscitation and mesenteric venous pressure elevation model, ACS was physiologically induced in 12 female Yorkshire swine. At decompression, animals were allocated to either NPT (n = 6) or Bogota bag (n = 6) as temporary abdominal closure and studied for a period of 48 h or until death. Outcomes measured included morbidity and mortality, as well as hemodynamic parameters, ventilator-related measurements, blood gases, coagulation factors, and organ (liver, kidney, lung, and intestinal) edema and histology at the time of death/sacrifice. All animals developed ACS. Early application of NPT was associated with decreases in mesenteric venous and central venous pressure, and significantly increased drainage of peritoneal fluid. In addition, there was no increase in the incidence of mortality, recurrent intra-abdominal hypertension/ACS, or any deleterious effects on markers of organ injury. Early application of NPT in this porcine ACS model is safe and does not appear to be...Continue Reading

References

Jan 31, 2002·Journal of Pediatric Surgery·S A EngumJ L Grosfeld
Oct 24, 2002·Shock·Christian ToensViolker Schumpelick
Oct 21, 2003·The Journal of Trauma·Alexander SchachtruppVolker Schumpelick
Mar 30, 2006·Critical Care : the Official Journal of the Critical Care Forum·Jan J De WaeleManu Lng Malbrain
Sep 4, 2007·The Journal of Surgical Research·Emanuel BenningerChristoph Meier
Apr 4, 2009·World Journal of Surgery·Zsolt J BaloghFrederick A Moore
Mar 12, 2010·The Journal of Trauma·Shinil K ShahCharles S Cox
Jan 1, 2007·Acta Clinica Belgica·A SchachtruppA Wilmer

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