Evaluating the functional state of adult-born neurons in the adult dentate gyrus of the hippocampus: from birth to functional integration

Reviews in the Neurosciences
Andrea Aguilar-ArredondoAngélica Zepeda

Abstract

Hippocampal neurogenesis occurs in the adult brain in various species, including humans. A compelling question that arose when neurogenesis was accepted to occur in the adult dentate gyrus (DG) is whether new neurons become functionally relevant over time, which is key for interpreting their potential contributions to synaptic circuitry. The functional state of adult-born neurons has been evaluated using various methodological approaches, which have, in turn, yielded seemingly conflicting results regarding the timing of maturation and functional integration. Here, we review the contributions of different methodological approaches to addressing the maturation process of adult-born neurons and their functional state, discussing the contributions and limitations of each method. We aim to provide a framework for interpreting results based on the approaches currently used in neuroscience for evaluating functional integration. As shown by the experimental evidence, adult-born neurons are prone to respond from early stages, even when they are not yet fully integrated into circuits. The ongoing integration process for the newborn neurons is characterised by different features. However, they may contribute differently to the network dep...Continue Reading

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Citations

Apr 28, 2016·Neuroscience and Biobehavioral Reviews·Estela Castilla-OrtegaLuis J Santín
Mar 27, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sherleen Xue-Fu AdamsonWei Zheng
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Apr 18, 2018·Brain Structure & Function·Andrea Aguilar-Arredondo, Angélica Zepeda

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